An Evaluation of the Efficacy of Amlexanox and Triamcinolone Topical Paste in the Treatment of Recurrent Aphthous Stomatitis

Abstract

Introduction: Recurrent aphthous stomatitis (RAS) is a common condition of the mucosa of oral cavity characterized by recurrent attacks of small, round or oval, painful affecting 5-25% of the general population and rarely involves genital region. These lesions occur most commonly on the nonkeratinized epithelium of oral cavity and ulcers heal within a period of 10-14 days with characteristic feature of pain causing difficulty on chewing, swallowing, and/or speaking. So, the purpose of present study was to evaluate the effectiveness of Amlexanox 5% and Triamcinolone 0.1% for the treatment of recurrent aphthous ulcers. Material and Methods: This double-blinded randomized clinical study done in the Department of Oral Medicine And Radiology, Government dental college Srinagar includes 36 patients suffering from recurrent aphthous ulcers aged between 25 and 55 years old and, having minor aphthous ulcers not more than 48 hours old. Group-1 was administered with Triamcinolone 0.1% (Kenocort 0.1% oral paste, Abbort Laboratories Chicago USA), while the group-2 was administered with Amlexanox 5% (Lexanox 5% oral paste, macleods Pharmaceuticals India). The patients used these pastes four times daily for 7 days. The patients were followed at days 0, 3, 5 and 7 and scores were assessed using visual analog scale. Results: The results showed that in both of the groups, there was reduction of pain and ulcer size significantly at subsequent follow up visits at 3 rd , 5 th and 7 th days (p< 0.01). None of the patients reported with pain in both the groups on 7 th day of treatment. No significant difference was noted between Triamcinolone and Amlexanox for their efficacy on pain relieving effect as well as on tingling in the present study. Conclusion: This study showed that both Amlexanox and Triamcinolone are active treatment options for RAS with no statistically significant difference between Amlexanox and Triamcinolone with regards to pain, tingling and ulcer size reduction.

Assessment of efficacy of 5% topical amlexanox and 0.1% topical triamcinolone acetonide in management of recurrent aphthous stomatitis

“…However, triamcinolone acetonide was found to be better as compared with amlexanox, which revealed one case of nonhealing. Chalkoo et al [ 11 ] in their study on 36 patients of recurrent aphthous ulcers assessed pain score, ulcer size, and tingling sensation. Patients in group I were administered with triamcinolone 0.1% (Abbott laboratories, Illinois, USA, 0.1% oral paste), and patients in group II were administered with amlexanox 5% (Macleods pharmaceuticals, Mumbai, India, 5% oral paste) four times daily for 1 week.…”