An evaluation of the microbiota of the upper reproductive tract of women with and without epithelial ovarian cancer

Brewster, Wendy R.; Burkett, Wesley; Ko, Emily; Bae‐Jump, Victoria L.; McCoy, Amber N.; Keku, Temitope O.

doi:10.1016/j.gore.2022.101017

Cited by 18 publications

(15 citation statements)

References 23 publications

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“…Not only is there a significant difference in the diversity and composition of the microbiomes between women with and without cancer (122,123), but the flora of different parts of the upper genital tract of women with ovarian cancer are also significantly different. A recent study that collected tissue flora of the proximal fallopian tube, fimbriae and ovaries in women with ovarian cancer found significant differences between the microbiomes of the different sites through high throughput sequencing of the 16S gene in the V1-V3 region (124). In terms of the early prediction of ovarian cancer, one study indicated a significant decrease in Lactococcus in ovarian cancer tissue, which may be a potential biomarker for identifying the disease.…”

Section: Gynecological Cancer Microbiomementioning

confidence: 99%

Vaginal and tumor microbiomes in gynecological cancer (Review)

et al. 2023

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Cervical, ovarian and endometrial cancer are the three most common types of gynecologic cancer. As a hub, the vagina connects the site of gynecological cancer with the external environment. Lactobacilli participate in the formation of a healthy vaginal microenvironment as the first line of defense against pathogen invasion; a dysbiotic vaginal microenvironment loses its original protective function and is associated with the onset, metastasis, poor efficacy and poor prognosis of gynecological cancer. The early diagnosis of cancer is the key to improve the survival time of patients with cancer. The screening of Porphyromonas, Sneathia and Atopobium vaginae, and other microbial markers, can assist the diagnosis of gynecological cancer, and screen out the high-risk population as early as possible. With the in-depth study of the microbes in tumor tissues, reasearchers have analyzed the immunological associations of microorganisms in tumor tissues. Due to the structural-functional interconnection between the organ of gynecological tumorigenesis and the vagina, the present study aims to review the relationship between vaginal and tumor microorganisms and gynecological cancer in terms of occurrence, screening, treatment and prognosis. Contents 1. Introduction 2. Vaginal microbes and the acidic vaginal environment 3. Vaginal microbes in gynecological malignancies 4. Tumor microbiome in gynecological malignancies 5. Prospects

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Section: Gynecological Cancer Microbiomementioning

confidence: 99%

Vaginal and tumor microbiomes in gynecological cancer (Review)

et al. 2023

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“…Our approach in collecting swabs in a sterile fashion in the operating room before the surgical case starts is unique and has not been used in previous studies (21)(22)(23). This approach enables us to evaluate the microbiota in each individual patient at multiple sites to infer transfer among sites.…”

Section: Discussionmentioning

confidence: 99%

“…Even the existence of a microbiota in the fallopian tube has not been convincingly demonstrated, in part due to the technical challenges of accessing this site in a sterile fashion. Several studies have provided evidence that the FT may not be sterile (21)(22)(23), but rigorous controls and large sample sizes are needed to assess the microbiota in low biomass samples. Here, we examine the fallopian tube microbiota from a large study population with collection of swabs in a sterile fashion in the operating room from both patients with ovarian cancer and those without.…”

Section: Introductionmentioning

confidence: 99%

Identification of fallopian tube microbiota and its association with ovarian cancer: a prospective study of intraoperative swab collections from 187 patients

Yu,

Liu,

Proll

et al. 2023

Preprint

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Investigating the human fallopian tube (FT) microbiota has significant implications for understanding the pathogenesis of ovarian cancer (OC). In this large prospective study, we collected swabs intraoperatively from the FT and other surgical sites as controls to profile the microbiota in the FT and to assess its relationship with OC. 81 OC and 106 non-cancer patients were enrolled and 1001 swabs were processed for 16S rRNA gene PCR and sequencing. We identified 84 bacterial species that may represent the FT microbiota and found a clear shift in the microbiota of the OC patients when compared to the non-cancer patients. Of the top 20 species that were most prevalent in the FT of OC patients, 60% were bacteria that predominantly reside in the gastrointestinal tract, while 30% normally reside in the mouth. Serous carcinoma had higher prevalence of almost all 84 FT bacterial species compared to the other OC subtypes. The clear shift in the FT microbiota in OC patients establishes the scientific foundation for future investigation into the role of these bacteria in the pathogenesis of ovarian cancer.

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“…Acidovorax, Acinetobacter, Aeromonas, Cloacibacterium, Conexibacter, Mariomonas, Methylobacterium, Propionibacterium, Pseudoalteromonas, Vibrio , and Xanthomonas spp. were less presented in upper reproductive tract tissues of ovarian cancer patients, while Bosea, Mesorhizobium, Mycobacterium, Ralstonia , and Variovorax were more prevalent in cancer tissues compared to control tissues ( 131 ). The study concerning the oncobiotic peritoneal microbiome demonstrated that ovarian cancer patients showed a unique peritoneal microbial profile compared to patients with a benign mass.…”

Section: The Study Of Tumor Microbiome In Various Solid Malignanciesmentioning

confidence: 92%

Tumor microbiome – an integral part of the tumor microenvironment

et al. 2022

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The tumor microenvironment (TME) plays a significant role in tumor progression and cancer cell survival. Besides malignant cells and non-malignant components, including immune cells, elements of the extracellular matrix, stromal cells, and endothelial cells, the tumor microbiome is considered to be an integral part of the TME. Mounting evidence from preclinical and clinical studies evaluated the presence of tumor type-specific intratumoral bacteria. Differences in microbiome composition between cancerous tissues and benign controls suggest the importance of the microbiome-based approach. Complex host-microbiota crosstalk within the TME affects tumor cell biology via the regulation of oncogenic pathways, immune response modulation, and interaction with microbiota-derived metabolites. Significantly, the involvement of tumor-associated microbiota in cancer drug metabolism highlights the therapeutic implications. This review aims to summarize current knowledge about the emerging role of tumor microbiome in various types of solid malignancies. The clinical utility of tumor microbiome in cancer progression and treatment is also discussed. Moreover, we provide an overview of clinical trials evaluating the role of tumor microbiome in cancer patients. The research focusing on the communication between the gut and tumor microbiomes may bring new opportunities for targeting the microbiome to increase the efficacy of cancer treatment and improve patient outcomes.

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An evaluation of the microbiota of the upper reproductive tract of women with and without epithelial ovarian cancer

Cited by 18 publications

References 23 publications

Vaginal and tumor microbiomes in gynecological cancer (Review)

Vaginal and tumor microbiomes in gynecological cancer (Review)

Identification of fallopian tube microbiota and its association with ovarian cancer: a prospective study of intraoperative swab collections from 187 patients

Tumor microbiome – an integral part of the tumor microenvironment

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