An evaluation of the mutagenic, carcinogenic and teratogenic potential of microwaves

Léonard, A.; Berteaud, A. J.; Bruyère, Antoine

doi:10.1016/0165-1110(83)90045-3

Cited by 47 publications

(10 citation statements)

References 49 publications

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“…It is therefore too early to commit oneself with unfounded mechanistic considerations. However, our results do agree with those obtained by other investigators for other frequencies and power densities [for review see Leonard et al, 1983;Garaj-Vrhovac et al, 1990, 1991d'Ambrosio et al, 19921. …”

Section: Resultssupporting

confidence: 93%

In vitro cytogenetic effects of 2450 MHz waves on human peripheral blood lymphocytes

Maes

Verschaeve

Arroyo

et al. 1993

Bioelectromagnetics

101

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Cytogenetic analyses were performed on human peripheral blood lymphocytes exposed to 2450 MHz microwaves during 30 and 120 min at a constant temperature of 36.1 degrees C (body temperature). The temperature was kept constant by means of a temperature probe put in the blood sample which gives feedback to a microcomputer that controls the microwave supply. We found a marked increase in the frequency of chromosome aberrations (including dicentric chromosomes and acentric fragments) and micronuclei. On the other hand the microwave exposure did not influence the cell kinetics nor the sister chromatid exchange (SCE) frequency.

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Section: Resultssupporting

confidence: 93%

In vitro cytogenetic effects of 2450 MHz waves on human peripheral blood lymphocytes

Maes

Verschaeve

Arroyo

et al. 1993

Bioelectromagnetics

101

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“…While some studies have not revealed significant genotoxicity (Leonard et al, 1983;Lloyd et al, 1986;Saunders et al, 1988), other studies have reported positive effects (Garaj-Vhrovac et al, 1990;Maes et al, 1993Maes et al, , 1995Singh, 1995, 1996;Adey, 1997;Phillips et al, 1998). These divergent results mostly derive from non-homogeneous experimental design.…”

Section: Discussionmentioning

confidence: 99%

Exposure to 900 MHz electromagnetic field induces an unbalance between pro‐apoptotic and pro‐survival signals in T‐lymphoblastoid leukemia CCRF‐CEM cells

Marinelli

Sala

Cicciotti

et al. 2003

Journal Cellular Physiology

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It has been recently established that low-frequency electromagnetic field (EMFs) exposure induces biological changes and could be associated with increased incidence of cancer, while the issue remains unresolved as to whether high-frequency EMFs can have hazardous effect on health. Epidemiological studies on association between childhood cancers, particularly leukemia and brain cancer, and exposure to low- and high-frequency EMF suggested an etiological role of EMFs in inducing adverse health effects. To investigate whether exposure to high-frequency EMFs could affect in vitro cell survival, we cultured acute T-lymphoblastoid leukemia cells (CCRF-CEM) in the presence of unmodulated 900 MHz EMF, generated by a transverse electromagnetic (TEM) cell, at various exposure times. We evaluated the effects of high-frequency EMF on cell growth rate and apoptosis induction, by cell viability (MTT) test, FACS analysis and DNA ladder, and we investigated pro-apoptotic and pro-survival signaling pathways possibly involved as a function of exposure time by Western blot analysis. At short exposure times (2-12 h), unmodulated 900 MHz EMF induced DNA breaks and early activation of both p53-dependent and -independent apoptotic pathways while longer continuous exposure (24-48 h) determined silencing of pro-apoptotic signals and activation of genes involved in both intracellular (Bcl-2) and extracellular (Ras and Akt1) pro-survival signaling. Overall our results indicate that exposure to 900 MHz continuous wave, after inducing an early self-defense response triggered by DNA damage, could confer to the survivor CCRF-CEM cells a further advantage to survive and proliferate.

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“…Studies on genotoxic potential effects of high‐frequency EMFs have been done in cell culture and animals. While some studies have not revealed significant genotoxicity (Leonard et al, 1983; Lloyd et al, 1986; Saunders et al, 1988), other studies have reported positive effects (Garaj‐Vhrovac et al, 1990; Maes et al, 1993, 1995; Lai and Singh, 1995, 1996; Adey, 1997; Phillips et al, 1998). These divergent results mostly derive from non‐homogeneous experimental design.…”

Section: Discussionmentioning

confidence: 99%

Tumor specific gene expression profiles in human leiomyosarcoma

Shmulevich

Hunt

El‐Naggar

et al. 2002

Cancer

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This work evaluates the ability of multiphase computational fluid dynamics (CFD) models to predict known flow regimes in air–water bubble columns. An initial grid‐resolution study shows that grid spacing of 0.25 cm or smaller must be used for adequate resolution. The ability of the two‐fluid model to predict homogeneous‐ and transitional‐flow behavior is analyzed next, and the flow predictions are found to be highly dependent on the model formulation (that is, bubble‐induced turbulence, drag, virtual mass, lift, rotation, and strain). At low gas velocities, homogeneous flow is observed for only a particular set of force models. At higher gas velocities, the same set of models yields reasonable predictions of transitional flow for small columns. Bubble size and liquid coflow also affect flow structures and flow stability at high gas flow rates. Scale‐up to larger column diameters is studied for both the homogeneous‐ and transitional‐flow regimes. In the homogeneous regime, the flow behavior is found to be independent of column diameter. However, because of neglect of coalescence, transition to churn‐turbulent flow is not observed at high gas velocities for large column diameters. © 2005 American Institute of Chemical Engineers AIChE J, 2005

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An evaluation of the mutagenic, carcinogenic and teratogenic potential of microwaves

Cited by 47 publications

References 49 publications

In vitro cytogenetic effects of 2450 MHz waves on human peripheral blood lymphocytes

In vitro cytogenetic effects of 2450 MHz waves on human peripheral blood lymphocytes

Exposure to 900 MHz electromagnetic field induces an unbalance between pro‐apoptotic and pro‐survival signals in T‐lymphoblastoid leukemia CCRF‐CEM cells

Tumor specific gene expression profiles in human leiomyosarcoma

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