. (2016). Cross-over study of novice intubators performing endotracheal intubation in an upright versus supine position. Internal and Emergency Medicine, 1-6. https://doi.org/10.1007/s11739-016-1481-z Novice Upright Intubation 2 Abstract: There are a number of potential physical advantages to performing orotracheal intubation in an upright position. The objective of this study was to measure the success of intubation of a simulated patient in an upright versus supine position by novice intubators after brief training. This was a cross-over design study in which learners (medical students, physician assistant students, and paramedic students) intubated mannequins in both a supine (head of the bed at 0 degrees) and upright (head of bed elevated at 45 degrees) position. The primary outcome of interest was successful intubation of the trachea. Secondary outcomes included log time to intubation, Cormack-Lehane view obtained, Percent of Glottic Opening score, provider assessment of difficulty, and overall provider satisfaction with the position. There were a total of 126 participants: 34 medical students, 84 physician assistant students, and 8 paramedic students. Successful tracheal intubation was achieved in 114 supine attempts (90.5%) and 123 upright attempts (97.6%; p = 0.283). Upright positioning was associated with significantly faster log time to intubation, higher likelihood of achieving Grade I Cormack-Lehane view, higher Percent of Glottic Opening score, lower perceived difficulty, and higher provider satisfaction. A subset of 74 participants had no previous intubation training or experience. For these providers, there was a non-significant trend toward improved intubation success with upright positioning vs supine positioning (98.6% vs. 87.8%, p = 0.283). For all secondary outcomes in this group, upright positioning significantly outperformed supine positioning.