The decision-making process is highly demanding. There has been an increasing tendency to incorporate human thinking, individual experience about a problem, and pure mathematical approaches. Here, a novel integrated approach is investigated and proposed to develop an advanced hybrid decision-support system based on the decision-making trial and evaluation laboratory (DEMATEL) and fuzzy cognitive maps (FCMs). Indeed, knowledge acquisition and elicitation may present distortions and difficulties finding a consensus and an interpretation. Thus, the proposed combined approach aims to examine in depth the potential to improve FCMs’ outcomes by integrating FCM with the DEMATEL approach. The combined methodology achieves at avoiding some of the drawbacks, such as the lack of a standardized FCM theoretical model. Thus, it provides advanced comparative analysis and results in better interpretation of the decision-making process. It is highlighted that the traditional FCM approach does not allow distinguishing the whole number of defined scenarios, in contrast to the hybrid one presented here, which increases the ability of users to make correct decisions. Combining the two approaches provides new capabilities to FCMs in grouping experts’ knowledge, while the DEMATEL approach contributes to refining the strength of concepts’ connections.