An Evaluation of the Safety and Immunogenicity of a Five-Component Acellular Pertussis, Diphtheria, and Tetanus Toxoid Vaccine (DTaP) When Combined With aHaemophilus influenzaeType b-Tetanus Toxoid Conjugate Vaccine (PRP-T) in Taiwanese Infants

Abstract

The five-component DTaP vaccine may be combined with PRP-T vaccine without clinically significant immunologic interaction when given in a 2-, 4-, 6-, and 18-month schedule.

Magnitude of Interference after Diphtheria‐Tetanus Toxoids–Acellular Pertussis/Haemophilus influenzaeType b Capsular Polysaccharide–Tetanus Vaccination Is Related to the Number of Doses Administered

“…This finding of decreased mean anti-tetanus toxoid antibody concentrations was found by others evaluating the same DTaP/PRP-T combination vaccine [4,6,10] and that of another manufacturer of the PRP-T vaccine [2,5], although no depression in anti-tetanus toxoid antibody responses was found in Taiwanese infants [11]. From the perspective of clinical relevance, only 2 patients who received the 3-dose regimen had a subprotective antibody concentration.…”

“…Depressed antibody responses to Haemophilus influenzae type b (Hib) usually have occurred [1][2][3][4][5][6][7] when a Hib vaccine and a diphtheria-tetanus toxoids-acellular pertussis (DTaP) vaccine have been combined together in the same syringe and used for the primary series of immunizations; insignificant interactions [8][9][10][11] also have been documented occasionally. Why the antiHib antibody response has been particularly vulnerable to interference when combined with DTaP vaccines or by what mechanism such antagonism occurs is unclear.…”

Naturally Acquired and Conjugate Vaccine-Induced Antibody to Haemophilus influenzae Type b (Hib) Polysaccharide in Malian Children: Serological Assessment of the Hib Immunization Program in Mali

“…Accordingly, this is the most frequently used measure to assess the immunogenicity of Hib conjugate immunization schedules and to predict protection that will endure throughout the period of risk for infants, toddlers, and pre-school children. 10,[19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] Moreover, a study in the Dominican Republic has indicated that even higher serum PRP antibody levels, 5.0 μg/mL, can be correlated with protection against upper respiratory tract colonization with Hib. 17 Since 2002, the Center for Vaccine Development -Mali (CVD-Mali), in Bamako (a collaborative enterprise maintained jointly by the Ministry of Health of Mali and the Center for Vaccine Development of the University of Maryland School of Medicine), has been conducting systematic surveillance studies of invasive pediatric bacterial infections among infants and children admitted to l'Hô pital Gabriel Touré, the one government hospital where severely ill children are admitted.…”

Combination Vaccines

“…Taiwan have evaluated a variety of DTaP/Hib combinations and similar results obtained [20,21]. All combinations are highly immunogenic when used to boost previously primed children.…”

“…Infants given a combined DTaP/ HepB/PRP-T vaccine experienced a significantly lower antibody response to the PRP-T component than infants given PRP-T vaccine as a separate injection. But after the booster dose the antibody levels were comparable and protective, signifying that the combination vaccine had successfully primed the immune system [20,21]. 4.…”