Borges de Souza and David Sample for the tireless guidance and patience with the discussions and for the friendship, encouragement and help in the difficult times faced in this challenge. To my brothers, nephews, family members and friends for the encouragement and understanding of my absence. To the NIBH family: each person, in his/her own way and time, helped me to overcome many difficulties. This is especially for arretada Clarissa Câmara de Freitas "Paraíba masculina, Muié macho, sim sinhô", everyone's supermom, always ready to everything and my partner all this time. Thank you very much! To the two enlightened people, best team that I could ever have: Marina Batalini de Macedo and Cesar do Lago. You are examples of smart, committed and engaged people. Together we managed our experiments "BIRENICE and GODOFREDO". With you, I learned, challenged myself and grew up. My eternal gratitude for all the shared moments! To the team Life Long Workout (God Team)! You are more than special people to me. You held, listened to and supported me in my sad and happy moments during the period in São Carlos, always willing to comfort me with some training and at Tomodaty or with barbecues on weekends. Friends who I want to have forever, my sincere thank you. Remember, Curitiba is right around the corner, I will be waiting you all there! To the sweetest couple, Gisela and Tomás, for the friendship, support and encouragement. To professor Fabiana de Nadai Andreoli and PUCPR, for the trust placed in me and all the support on this journey. Thank you very much! To my great friend and adviser, Wilson José Galheira, for the friendship, support and encouragement. You will always be my personal and professional references. To my friends Mariana Kitamura and Henrique Lima, who, even from the distance, have always been present along this journey. Special thanks to my favorite baiana monster, Mariana Rivera Freire, for the help, care and dedication. To Sá and Priscilla, efficient secretaries of PPGSHS, for all the attention and understanding. In memory of my dear friend, Marcelo Bronze, for the support, encouragement, conversations and laughter. The one who reminded me almost daily the 3F quote: Strength (Força), Faith (Fé) and Focus (Foco). You were and always will be remembered. My eternal admiration. In memory of Dr. Hercília Laura Ferrari Cocicov, for the long conversations and encouragement. Thank you for showing me, in practice, that with work, love and dedication, it is possible to go further. Wherever you are, receive my love, gratitude and admiration. I thank the University of São Paulo for the physical structure and FAPESP and CNPq for granting me full scholarship, which made possible to accomplish this PhD. To all who believed it would be possible to accomplish this journey. Anyway, to God, responsible for our existence. EPÍGRAFE "I told you, but I will repeat: not dam a river, do not fool nature, make the dam you want, because the river sooner or later will find a way to tear the earth open a path, and return to run on his bed...