The objective of this study is to assess the effects of combined applications of recommended traditional chemical fertilization NPK 100% without Vinasse and with 100, 75, 50 NPK + Vinasse on Physio-Biochemical, root, shoot traits, yield, and its attributes for four faba bean Giza-429, Giza-843, Misr-2 and Sakha-3 genotypes which are cultivated in the soil is salt affected of eastern Egypt. The experimental design was conducted using a strip-plot design with three replicates in 2020 and 2021. Treatments of different doses of chemical fertilization were 100% NPK without Vinasse and 100%, 75%, and 50% of NPK with Vinasse as supplementary organic fertilizer were arranged in vertical strips, while horizontal strips were devoted to faba bean genotypes (Vicia faba L.) i.e. Giza-429, Giza-843, Misr-2, and Sakha-3. Relative to the other fertilizer combinations, the 75% NPK + Vinasse did not contribute more than 5% more yield to Sakha 3 than it did with the 100% NPK + Vinasse. Both the fertilizer and cultivar main effects had the same positive linear trend, with relatively higher total seed yield in the case of the 75% NPK + Vinasse and of cv. Sakha 3. The harvest index (HI) was different only for fertilizer levels.The 75% NPK + Vinasse differed by a very negligible margin from the 100% NPK + Vinasse, but both differed from the other two levels. Along with seed yield, both straw and biological yields were significant for the interaction effects, as well as for the main effects. Within all fertilizer combinations, cultivars Giza 843 and Saka 3 consistently, as a subgroup, outyielded the other two cultivars, not only for total seed yield but also for all other yield component characters.