An evaporation-assisted dispersive liquid–liquid microextraction technique as a simple tool for high performance liquid chromatography tandem–mass spectrometry determination of insecticides in wine

Timofeeva, Irina; Kanashina, Daria; Москвин, Л. Н.; Bulatov, Andrey

doi:10.1016/j.chroma.2017.07.034

Cited by 23 publications

(6 citation statements)

References 29 publications

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“…highly volatile. 21 In this work, three different volatile solvents were employed to extract analytes: CH 2 Cl 2 , CS 2 , and CHCl 3 . The recovery rates achieved using them are illustrated in Fig.…”

Section: Resultsmentioning

confidence: 99%

“…20 More recently, evaporation-assisted DLLME (EVA-DLLME) has been developed to identify pesticide levels in wine. 21 EVA-DLLME involves heating an aqueous sample with a mixture of organic solvents comprised of a low-density extraction solvent and a high-density volatile solvent. Droplets of extraction solvent move from the bottom of the sample solution to the top as the volatile solvent evaporates, enhancing the rate of microextraction.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Rapid analysis of triazine herbicides in fruit juices using evaporation-assisted dispersive liquid–liquid microextraction with solidification of floating organic droplets and HPLC-DAD

Niu

et al. 2022

Anal. Methods

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Rapid analysis of triazine herbicides in fruit juices using evaporation-assisted dispersive liquid–liquid microextraction with solidification of floating organic droplets and HPLC-DAD

Niu

et al. 2022

Anal. Methods

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“…For the examination of pesticides in nutraceutical drops, dispersive liquid–liquid microextraction (DLLME) should be an appropriate extraction technique. It is necessary to use an additional organic disperser solvent in DLLME, which often lowers the hydrophobic analytes’ partition coefficients into the extraction solvent [ 19 , 20 ]. Consequently, alcohol-containing samples, like nutraceutical drops, might be of interest to DLLME.…”

Section: Introductionmentioning

confidence: 99%

Fast DLLME-GC-MS Method for Determination of Pesticides in Carmelite Drops and Evaluation of Matrix Effects in Related Medicinal Products

Szarka,

Hrouzková

2024

Foods

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The production of nutraceuticals is a growing trend, as many consumers consider them an important part of the modern active lifestyle. Others rely on the use of nutraceuticals instead of prescribing pharmaceuticals to improve their health more naturally. One of the major concerns in the nutraceutical industry is the potential presence of contaminants. Even low concentrations of contaminant residues can be harmful, so analytical methods that are sensitive at ultratrace levels are needed. Dispersive liquid–liquid microextraction method combined with fast gas chromatography and mass spectrometry was developed for the inspection of pesticide residues in Carmelite drops. The most suitable recoveries are presented when the alcohol content is fixed at 20% in Carmelite drops. The method was validated; the linearity, limits of detection/quantification, the method accuracy and precision were obtained. The complex nutraceutical matrix causes significant complications in quantitative analysis; therefore, the main target of the work was placed on studying the effects of the matrix on the correct expression of the resulting concentration of contaminants in different types of samples. An in-depth study of matrix factors was carried out, and its relationship with the content of potential interferents from the medicinal products as well as other components added during the drops’ production was discussed. Related medicinal plant-derived nutraceuticals were tested, the method was applied for real-life samples, and positive findings are herein reported.

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“…On the other hand, the dispersive liquid-liquid microextraction (DLLME), developed by Rezaee et al, in 2006 [9], is recognized for its simplicity, low cost, and high ER. Thus far, DLLME has been applied for the extraction of a wide range of compounds from wine, such as phenols [10], phthalic acid esters [11], mycotoxins [12] and pesticides [13][14][15][16][17][18][19][20][21]. As far as this last category is concerned, to the best of our knowledge, only four methods applied the DLLME by using a green extraction solvent, such as 1-undecanol [14] and 1-octanol [15], or 1-dodecanol [16] and a hydrophobic eutectic solvent based on thymol and octanoic acid [17].…”

Section: Introductionmentioning

confidence: 99%

“…However, these last two methods have been developed for the extraction of less than five compounds. Moreover, there is a further DLLME which is not properly green because of the use of dichloromethane as an extraction solvent [18].…”

Section: Introductionmentioning

confidence: 99%

Hydrophobic Eutectic Solvent-Based Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Pesticides in Wine

2022

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A green solvent-based DLLME/HPLC-MS method for the determination of 19 pesticides in wine samples has been developed. The extractant solvent is a hydrophobic eutectic mixture composed of L-menthol and butylated hydroxytoluene in a molar ratio of 3:1. The endogenous ethanol of wine has been used as dispersive solvent, in order to avoid the solidification of the extracts under 19 °C. The mobile phase composition, the elution gradient and the sample injection volume were optimized in order to make this hydrophobic mixture compatible with conventional reversed phase chromatography and electrospray ionization. The method was validated in matrix, using a wine free from the target compounds. Average recovery as high as 80%, precision between 3 and 14%, and limits of detection and quantification much lower than the maximum residue levels (MRLs) for grapes and wines fixed by the EU regulation, make this multiresidue method fitted for the purpose, with the further advantages of being quick, cheap and in compliance with the green analytical chemistry. From the analysis of 11 commercial wines it was found that just in a bio sample the target compounds were not detectable or lower than quantification limit; as for the other samples, the most widespread and abundant pesticides were methoxyfenozide and boscalid, but their levels were much lower than the relative MRLs.

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An evaporation-assisted dispersive liquid–liquid microextraction technique as a simple tool for high performance liquid chromatography tandem–mass spectrometry determination of insecticides in wine

Cited by 23 publications

References 29 publications

Rapid analysis of triazine herbicides in fruit juices using evaporation-assisted dispersive liquid–liquid microextraction with solidification of floating organic droplets and HPLC-DAD

Rapid analysis of triazine herbicides in fruit juices using evaporation-assisted dispersive liquid–liquid microextraction with solidification of floating organic droplets and HPLC-DAD

Fast DLLME-GC-MS Method for Determination of Pesticides in Carmelite Drops and Evaluation of Matrix Effects in Related Medicinal Products

Hydrophobic Eutectic Solvent-Based Dispersive Liquid-Liquid Microextraction Applied to the Analysis of Pesticides in Wine

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