An Event‐Related Potential Study of Response Inhibition in ADHD With and Without Prenatal Alcohol Exposure

Burden, Matthew J.; Jacobson, Joseph L.; Westerlund, Alissa; Lundahl, Leslie H.; Morrison, Audrey; Dodge, Neil C.; Klorman, Rafael; Nelson, Charles A.; Avison, Malcolm J.; Jacobson, Sandra W.

doi:10.1111/j.1530-0277.2009.01130.x

Cited by 49 publications

(46 citation statements)

References 54 publications

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“…Children with PAE were also found to have more difficulties with conditions associated with over-arousal, whereas children with ADHD and no history of PAE demonstrated deficits in conditions of underarousal [101]. Additional group differences have been reported in the pattern of neural processing using eventrelated potentials as outcome measures on an inhibition task [102] and in responses to a conditioned eye blink task, with longer latencies and poorly timed responses among those with PAE compared to those with ADHD [103]. In contrast, children with ADHD had more difficulties with basic motor control, focused attention, sustained attention, and information retrieval.…”

Section: Child Psychiatry Hum Devmentioning

confidence: 89%

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Kable

O’Connor

Olson

et al. 2015

Child Psychiatry Hum Dev

107

101

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Over the past 40 years, a significant body of animal and human research has documented the teratogenic effects of prenatal alcohol exposure (PAE). Neurobehavioral Disorder associated with PAE is proposed as a new clarifying term, intended to encompass the neurodevelopmental and mental health symptoms associated with PAE. Defining this disorder is a necessary step to adequately characterize these symptoms and allow clinical assessment not possible using existing physically-based diagnostic schemes. Without appropriate diagnostic guidelines, affected individuals are frequently misdiagnosed and treated inappropriately (often to their considerable detriment) by mental health, educational, and criminal justice systems. Three core areas of deficits identified from the available research, including neurocognitive, self-regulation, and adaptive functioning impairments, are discussed and information regarding associated features and disorders, prevalence, course, familial patterns, differential diagnosis, and treatment of the proposed disorder are also provided.

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Section: Child Psychiatry Hum Devmentioning

confidence: 89%

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Kable

O’Connor

Olson

et al. 2015

Child Psychiatry Hum Dev

107

101

View full text Add to dashboard Cite

show abstract

“…Since we only found the association between MAOA with the inhibition function evaluated by the BRIEF scale but not the Stroop test, it will compel us to consider that the association between MAOA with inhibition function may exist in some other dimensions but not that demonstrated by the Stroop test we have used. In the literature, some tests were used to evaluate motor inhibition in ADHD and demonstrated impairment, such as Continuous Performance Test (CPT) [Soreni et al, 2009], Stop-signal Task (SST) [Sergeant et al, 2002;Lipszyc and Schachar, 2010], Test of Variables of Attention (TOVA) [Manor et al, 2002], and Go/no-go task [Solanto et al, 2009;Burden et al, 2010]. In addition, some other indices apart from the Stroop interference effect have attracted attention including latent inhibition, or priming, which represents the response to a stimulus that was previously ignored [Christiansen and Oades, 2010;Kaplan and Lubow, 2011] and which influences the Stroop interference effect [Appelbaum et al, 2009].…”

Section: Discussionmentioning

confidence: 99%

Association analyses of MAOA in Chinese Han subjects with attention‐deficit/hyperactivity disorder: Family‐based association test, case–control study, and quantitative traits of impulsivity

Liu

Guan

Chen

et al. 2011

American J of Med Genetics Pt B

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Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Genetic studies have found an association between MAOA and attention-deficit/hyperactivity disorder (ADHD), especially impulsivity. However, there has been inconsistency among studies which may be due to the complexity and heterogeneity of ADHD, including its sexual dimorphism and the presence of several subtypes. We conducted transmission disequilibrium tests (TDTs) in 1,253 trios and found no association between five single nucleotide polymorphisms (SNPs) of MAOA with ADHD in general or in the predominantly inattentive (ADHD-I) or combined types (ADHD-C), but with the predominantly hyperactive/impulsivity type (ADHD-HI). The association with MAOA was restricted to males, especially males with ADHD-HI. Logistic regression analyses of data from 1,824 cases and 957 controls did not indicate any association. We used analysis of covariance to analyze the association between MAOA genotype with the "inhibit" factor of the Behavior Rating Inventory of Executive Function (BRIEF) in 640 probands and performance on the Stroop test in 810 probands. Probands homozygous for risk alleles found in the TDT test had higher "inhibit" scores on the BRIEF scale which represents more severe impulsivity; this results also was restricted to males. No association was found with Stroop test performance. In conclusion, our results provide some evidence that MAOA may be associated with the ADHD-HI subtype and support the association between MAOA and impulsivity, which may be a potential endophenotype of ADHD. However, the results were strongly influenced by gender.

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“…Behaviors associated with the effects of PAE appear similar to behaviors observed in children with attention deficit hyperactivity disorder (ADHD) [53][54][55][56]. However, there are differences between the two disorders [55,56].…”

Section: Fasd and Problematic Behaviormentioning

confidence: 59%

Educational Needs and Care of Children with FASD

Millians

2015

Curr Dev Disord Rep

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The effects from prenatal alcohol exposure (PAE) can cause a range of neurobehavioral deficits that impact learning and functioning in school. As a result, children affected by PAE have diverse learning needs and may experience problems in school. Educational planning needs to be developed in accordance with the children's individual cognitive and learning profiles. Interventions need to focus on habilitation of the underlying deficits that influence learning within the context of an academic or school skill. Caregivers require information on how to advocate for their children's needs. Additionally, families, school personnel, and other professionals require training on the impact of PAE on development, learning, and school functioning. Using a comprehensive and collaborative approach to provide the necessary educational care for children with fetal alcohol spectrum disorders (FASD) may lessen the risk of academic and school failure.

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An Event‐Related Potential Study of Response Inhibition in ADHD With and Without Prenatal Alcohol Exposure

Cited by 49 publications

References 54 publications

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Neurobehavioral Disorder Associated with Prenatal Alcohol Exposure (ND-PAE): Proposed DSM-5 Diagnosis

Association analyses of MAOA in Chinese Han subjects with attention‐deficit/hyperactivity disorder: Family‐based association test, case–control study, and quantitative traits of impulsivity

Educational Needs and Care of Children with FASD

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