An Evidence-Based Approach to the Treatment of Gastroesophageal Reflux Disease

Patti, Marco G.

doi:10.1001/jamasurg.2015.4233

Cited by 111 publications

(93 citation statements)

References 69 publications

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“…11 A study by Shaheen et al, who analyzed the healthcare costs for gastrointestinal and liver diseases, reported that in 2004 the sales of PPIs in the United States reached 10 billion dollars. 12 A proper work-up for patients with GERD-related symptoms could dramatically reduce this expense.…”

Section: Discussionmentioning

confidence: 99%

Importance of Esophageal Manometry and pH Monitoring in the Evaluation of Patients with Refractory Gastroesophageal Reflux Disease: A Multicenter Study

Andolfi

Bonavina

Kavitt

et al. 2016

Journal of Laparoendoscopic & Advanced Surgical Techniques

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Section: Discussionmentioning

confidence: 99%

Importance of Esophageal Manometry and pH Monitoring in the Evaluation of Patients with Refractory Gastroesophageal Reflux Disease: A Multicenter Study

Andolfi

Bonavina

Kavitt

et al. 2016

Journal of Laparoendoscopic & Advanced Surgical Techniques

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“…In fact, up to 40% of patients fail to respond to PPIs, and there is an increasing concern that long‐term PPI maintenance may cause side effects such as reduced bone mineral density bone fracture and increasing the risk of myocardial infarction (MI), which has attracted more and more attention .Theoretically, prokinetic agents can improve the ability of esophageal acid clearance by enhancing esophageal peristalsis and augmenting the tension of LES, fundamentally preventing the occurrence of GERD; however, effective target drugs have not been developed. Additionally, successful antireflux surgery, such as Nissen fundoplication, can significantly reduce the chance of recurrence, but surgical complications and mortality are still a disturbing question concerning some surgeons’ experience and technique level .…”

Section: Introductionmentioning

confidence: 99%

Ameliorating Effects of Transcutaneous Electrical Acustimulation Combined With Deep Breathing Training on Refractory Gastroesophageal Reflux Disease Mediated via the Autonomic Pathway

Wei

Liu

et al. 2019

Neuromodulation: Technology at the Neural Interface

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Aims To investigate the effects and possible mechanisms of transcutaneous electrical acustimulation (TEA) combined with deep breathing training (DBT) on refractory gastroesophageal reflux disease (rGERD). Methods Twenty‐one patients with rGERD were recruited and randomly assigned to receive either only esomeprazole (ESO, 20 mg bid) (group A, n = 7), TEA + DBT + ESO (group B, n = 7), or sham‐TEA + DBT + ESO (group C, n = 7) in a four‐week study. The reflux diagnostic questionnaire (RDQ) score and heart rate variability (HRV) were recorded and evaluated at baseline and at the end of each treatment. Blood samples were collected for the measurement of serum acetylcholine (Ach) and nitric oxide (NO). Esophageal manometry and 24‐hour pH monitoring were performed before and after the treatment. Results After treatment, 1) the participants in group B had significantly lower scores of RDQ and DeMeester and increased lower esophageal sphincter pressure (LESP) than those in group C (all p < 0.05), suggesting the role of TEA; 2) low frequency band (LF)/(LF + HF) ratio in groups B and C was decreased, compared with group A (p = 0.010, p = 0.042, respectively); high frequency band (HF)/(LF + HF) ratio in B and C groups was significantly increased, compared with group A (p = 0.010, p = 0.042, respectively); 3) The serum Ach in groups B and C was significantly higher than group A (p = 0.022, p = 0.046, respectively); the serum NO in groups B and C was significantly lower than group A (p = 0.010, p = 0.027, respectively). Conclusions TEA combined with the DBT can effectively improve the reflux symptoms in rGERD patients by increasing LESP and reducing gastroesophageal reflux, which may be mediated via the autonomic and enteric mechanisms.

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“…8,23 Multiple studies have also concluded that a combination of hormonal changes and physical alterations increases the vulnerability of pregnant women to GORD especially in the third trimester. [24][25][26] The management of GORD includes both nonpharmacological and pharmacological approaches. Nonpharmacological treatment options include lifestyle modifications including changes in diet, sleeping posture, and weight reduction.…”

Section: Introductionmentioning

confidence: 99%

Raft‐forming polysaccharides for the treatment of gastroesophageal reflux disease (GORD): Systematic review

Yousaf

Nirwan

Smith

et al. 2019

J of Applied Polymer Sci

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Gastroesophageal reflux disease (GORD) is a common condition induced by unwarranted reflux of gastric and duodenal contents into the esophagus, and insufficient clearance of refluxate from it. Pharmaceutical formulations possessing raft‐forming capability offers an excellent alternative to conventional treatment options to treat uncomplicated GORD. These formulations typically contain a polymer, which performs distinctively upon contact with gastric acid and develops a foam‐like structure that can float on gastric contents. This review aims to feature research articles and patents that cover this topic. After undergoing a standardized literature search following preferred reporting items for systematic reviews and meta‐analyses guidelines, we have included 38 research articles and 18 patents describing the role of raft‐forming polymers in the treatment of GORD. This is a comprehensive review of formulation/testing of raft‐forming polymers. As expected, the majority of the studies focused on alginate; however, fewer studies have reported the use of pectin, xanthan gum, and raw psyllium fibers (husk). Moreover, it can be concluded from this comprehensive systematic review that a detailed characterization of raft‐forming formulations, type, and concentration of used active and inactive materials and different formulations factors are essential for the development of successful anti‐reflux raft‐forming formulations. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48012.

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An Evidence-Based Approach to the Treatment of Gastroesophageal Reflux Disease

Abstract: Gastroesophageal reflux disease is a highly prevalent disease. Once the diagnosis has been established, the best results are obtained by a multidisciplinary team with the goal of individualizing treatment for patients.

Cited by 111 publications

References 69 publications

Importance of Esophageal Manometry and pH Monitoring in the Evaluation of Patients with Refractory Gastroesophageal Reflux Disease: A Multicenter Study

Importance of Esophageal Manometry and pH Monitoring in the Evaluation of Patients with Refractory Gastroesophageal Reflux Disease: A Multicenter Study

Ameliorating Effects of Transcutaneous Electrical Acustimulation Combined With Deep Breathing Training on Refractory Gastroesophageal Reflux Disease Mediated via the Autonomic Pathway

Raft‐forming polysaccharides for the treatment of gastroesophageal reflux disease (GORD): Systematic review

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