An evidence-based causal model of panic disorder

Impaired cognitive reappraisal in panic disorder revealed by the late positive potential

“…Furthermore, these results support the hypothesis that abnormal (catastrophic) appraisals trigger and maintain panic attacks [3], and provide the first electrophysiological correlates for impaired cognitive reappraisal in patients with PD. A simultaneous EEG and functional MRI recording study revealed that the LPP originates in the visual cortices and emotion-processing structures such as the amygdala and prefrontal cortex [20].…”

“…The principal manifestations of PD include sudden, recurrent, and unexpected bursts of panic attack [2]. In the cognitive model of PD, panic attacks result from catastrophic misappraisal of bodily sensations, which may become conditioned stimuli that trigger and maintain the panic attacks [3].…”

“…Death, disease, and threat-related images were selected as unpleasant stimuli, which allowed predictions based on the catastrophic misappraisal hypothesis of PD [3]. We hypothesized that patients with PD would have undifferentiated LPP amplitudes for unpleasant images preceded by negative and neutral descriptions.…”

Cardiorespiratory concerns shape brain responses during automatic panic-related scene processing in patients with panic disorder

“…15,16 Anxiety severity is associated with the development of spontaneous panic attacks in healthy young adults, and fear of physical concerns (a subcomponent of anxiety severity) plays a particularly important role in predicting the course of panic disorder. [17][18][19][20] A better understanding of the role of anxiety severity in panic disorder could thus help to design prevention programs, specify therapeutic interventions and might further enrich diagnostic processes. Poletti and colleagues 21 reported positive correlations of anxiety severity with neural activation in the PFC, ACC and insula in patients with panic disorder.…”

Panik Bozukluğu Olan Hastalarda Obsesif İnançlar

“…Tıbbi ortamlarda en sık rastlanan anksiyete bozukluğu olan Panik Bozukluğunun genel nüfusta yaygınlık oranı %1-2 olarak bildirilmiştir (13,14,15). Panik Bozukluğunun bilişsel kavramsallaştırılmasında 'abartılmış tehdit algısı', içsel (interoseptif) duyumlara hatalı ya da katastrofik anlamlar verme ve artmış anksiyete duyarlılığına vurgu yapılmaktadır (16 Çalışmada kullanılan gereçler Hastaların sosyodemografik ve klinik özelliklerini değerlendirmek amacıyla DSM-IV SCID-I-CV klinik görüşme kılavuzundan uyarlanan form kullanıldı. First ve ark.…”