An Evidence-Based Definition of Lifelong Premature Ejaculation: Report of the International Society for Sexual Medicine (ISSM) Ad Hoc Committee for the Definition of Premature Ejaculation

McMahon, Chris G.; Althof, Stanley E.; Waldinger, Marcel D.; Porst, Hartmut; Dean, John; Sharlip, Ira D.; Adaikan, P.G.; Becher, Edgardo; Broderick, Gregory A.; Buvat, J.; Dabees, Khalid; Giraldi, Annamaria; Giuliano, François; Hellstrom, Wayne J.G.; Incrocci, Luca; Laan, Ellen; Meuleman, E.J.H.; Perelman, Michael A.; Rosen, Raymond C.; Rowland, David L.; Segraves, Robert

doi:10.1111/j.1743-6109.2008.00901.x

Cited by 375 publications

(395 citation statements)

References 85 publications

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“…The International Society for Sexual Medicine (ISSM) convened a meeting on October 2007 and defined life-long PE as 'a male sexual dysfunction characterized by ejaculation which always or nearly always occurs before or within about one minute of vaginal penetration; and, inability to delay ejaculation on all or nearly all vaginal penetrations; and, negative personal consequences, such as distress, bother, frustration and/or the avoidance of sexual intimacy'. 7 Unlike DSM-IV-TR, this definition clearly defined PE in terms of an IELT of about 1 min. However, at the time of the commencement of our study this definition did not exist; therefore the diagnosis of men with PE was on the basis of the most widely accepted definition at that time.…”

Section: Discussionmentioning

confidence: 99%

Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time

Şerefoğlu¹,

Çimen²,

Özdemır³

et al. 2008

Int J Impot Res

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There are uncertain issues on the diagnostic methods of premature ejaculation (PE). The premature ejaculation diagnostic tool (PEDT) was developed to systematically apply the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria in diagnosing PE and the aim of this study is to carry out the Turkish validation of the PEDT and to evaluate its association with intravaginal ejaculatory latency time (IELT). A total of 94 patients with a self-reported complaint of PE and 88 men without PE were enrolled into the study and requested to complete the nine-item PEDT, which was translated into Turkish. The patients were also requested to measure IELT. All participants were requested to come for a second visit to assess the PEDT's retest reliability; data from 78 men in the PE group and 69 men in the control group were collected. The IELT data of 35 patients were also recorded. The mean age of the PE group and the control group were 39.4±9.7 (24-65) and 30.1±5.7 (20-56), respectively, (P ¼ 0.068). Among the patients in the PE group, 24 (68.5%) reported life-long PE, whereas 11 (31.5%) reported acquired PE. The geometric mean IELT of the PE group was 59.7 ± 46.2 (6.5-197.7) s. The number of men reporting IELTs of o1, 1-o2 and 42 min were 20 (57.1%), 11 (31.5) and 4 (11.4%), respectively. The factor analysis assessment showed that the five-item combination (questions 1, 2, 3, 4 and 8) explained 74.4% of the variance, there were no other combinations that explained the variance more effectively. Cronbach's alpha score of five-item combination was calculated as 0.77, showing adequate internal consistency. The overall Cronbach's alpha score did not increase if any item combination was deleted. The test-retest correlation coefficients of each item were higher than 0.80 and the correlation coefficient of the total score was 0.90. The PEDT and IELT showed an adequate correlation (q ¼ 0.44). As a conclusion, the validated five-item Turkish version of PEDT is a reliable questionnaire to screen PE among Turkish patients. Its significant association with IELT supports the fact that PEDT may be of benefit for the diagnosis of PE and measuring the response to treatment. In addition, PEDT seems to be more applicable than measuring IELT in our population, for the assessment of PE.

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Section: Discussionmentioning

confidence: 99%

Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time

Şerefoğlu¹,

Çimen²,

Özdemır³

et al. 2008

Int J Impot Res

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“…5,6 The ISSM (International Society for Sexual Medicine) Ad Hoc Committee for the Definition of PE defines lifelong PE as a male sexual dysfunction characterized by: ejaculation that always or nearly always occurs before or within approximately 1 min of vaginal penetration; the inability to delay ejaculation on all or nearly all vaginal penetrations; negative personal consequences such as distress, bother, frustration and/or the avoidance of sexual intimacy. 7 Premature ejaculation can be classified as either a lifelong condition (present since the onset of sexual maturity) or an acquired condition that develops after an interval of normal sexual function. 8 Although both biological and psychological factors are important in the etiology, the underlying physiopathology of this condition is not well understood.…”

Section: Introductionmentioning

confidence: 99%

“…Prevalence of PE is higher than erectile dysfunction, ranging from 9 to 31% in the general male population. 7 Obesity and the MS are associated with erectile dysfunction. 9,10 However, the relationship between obesity and PE has not yet been specifically investigated.…”

Section: Introductionmentioning

confidence: 99%

Insight on pathogenesis of lifelong premature ejaculation: inverse relationship between lifelong premature ejaculation and obesity

Gökçe

Ekmekçioğlu

2010

Int J Impot Res

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Although both biological and psychological factors are important in the etiology, the exact pathogenesis of lifelong premature ejaculation (PE) remains to be clarified. Obesity is a worldwide epidemic that contributes to many chronic diseases. Obesity is associated with erectile dysfunction, but the relationship between obesity and PE has not yet been specifically investigated. The aim of this study was to evaluate the relationships of these two conditions. Between January 2008 and December 2009, we evaluated consecutive patients with lifelong PE in the urology outpatient clinic. Control cases without lifelong PE were selected randomly among cases attending the department of internal medicine for a checkup procedure. The age and sex of control group were matched with that of the study group. Body mass index (BMI) of each case was calculated using the World Health Organization criteria by the measurements of the physician instead of relying on verbal expressions. The mean (±s.d.) age of the premature ejaculators was 31.7±5.7 (range 21-51) years and in the control cases it was 32.3±6.7 (range 22-54) years. The comparison of the mean (±s.d.) weight between the study (74.1 ± 11.2 kg) and control groups (81.9 ± 6.4 kg) revealed a significant difference (Po0.001). The mean BMI of premature ejaculators (24.9 ± 3.4 kg m -2 ) was lower than the mean BMI of control (27.5±3.6 kg m -2 ; Po0.001). As the BMI increased, the number of patients decreased in the PE group. The number of the obese cases in the control group (n ¼ 26, 24.1%) was three times greater than the obese premature ejaculators (Po0.005), and the number of PE patients were approximately two times greater than the control cases in the normal-weight class (Po0.001). This is the first prospective study that investigated the relationship between lifelong PE and obesity, and we found that patients with lifelong PE were leaner than the healthy control cases.

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“…PE was defined as ejaculation 'within about 1 min' according to the PE guidelines of the International Society for Sexual Medicine (ISSM). 14 …”

Section: Methodsmentioning

confidence: 99%

Impact of erectile function and age in men with lower urinary tract symptoms on ejaculatory dysfunction and premature ejaculation

et al. 2012

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Lower urinary tract symptoms (LUTSs) and ED are clearly correlated, but to date no correlation with ejaculatory dysfunction (EjD) has been identified. Therefore, this study evaluated the impact of erectile function in men with LUTS on EjD and premature ejaculation (PE). Erectile function, PE and EjD of 239 men (mean age, 53.0±10.65 years), International Prostate Symptom Score (IPSS), International Index of Erection Function (IIEF), intravaginal ejaculatory latency time (IELT) and the seven-item Male Sexual Health questionnaire (MSHQ)-EjD were used to compare with the degree of LUTS. Ages were divided into five groups (o40, 40 --49, 50 --59, 60--69 and 470 years). The IPSS categorized patients into three symptom groups: mild, 1 --7; moderate, 8 --19; and severe, 419. ED was classified into five categories based on IIEF-EF scores: severe (0 --6), moderate (7 --12), mild-to-moderate (13--18), mild (19 --24) and normal (25 --30). The correlations among age, IIEF-EF, IELT and the MSHQ-EjD domain were studied through regression and cross-tabulation analyses. The results revealed that aging significantly affected each item of the MSHQ-EjD (Po0.05). The IIEF-EF domain was also correlated with each question on the MSHQ-EjD (Po0.05). PE (IELT o1 min) increased in incidence as patients got older but was not linked to IIEF-EF (P40.05). These results indicate that EjD is closely related to age and erectile function, and that PE is closely related to age, although PE is not related to erectile function. INTRODUCTIONRepresentative symptoms that may develop with aging include lower urinary tract symptoms (LUTSs) and ED. These two symptoms are not simply the result of aging, and they have a common pathophysiology. Thus, by treating one disease, a synergistic effect of treating the other disease may occur simultaneously. 1,2 A multinational questionnaire survey involving 12 815 men older than 50 years revealed that the two diseases are associated, and for those with ED, age and LUTS were more potent risk factors than diabetes, hypertension or hyperlipidemia. 3 Ejaculation is the process of sperm transport from the epididymis to the urethral meatus, resulting in the expulsion of semen. Ejaculation occurs in two phases: seminal emission and ejaculation proper, and they are mediated by sympathetic and parasympathetic inputs, respectively. When sexual stimulation is extremely intense, the autonomic impulses responsible for the emission phase exit the spinal cord at the T10 --L2 level via sympathetic chains, course into the pelvis as hypogastric outflow and onto the genital structures involved in ejaculation. Parasympathetic and somatic inputs from S2 to S4 then cause ejaculation proper, and antegrade ejaculation occurs. 4,5 If the ejaculation reflex takes place too quickly, it may induce premature ejaculation (PE). In contrast, if it is late, delayed ejaculation may occur. Abnormalities in the sympathetic nerves or deterioration in male hormone levels because of aging may reduce semen volume or ejaculation force and decrease the fre...

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An Evidence-Based Definition of Lifelong Premature Ejaculation: Report of the International Society for Sexual Medicine (ISSM) Ad Hoc Committee for the Definition of Premature Ejaculation

Cited by 375 publications

References 85 publications

Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time

Turkish validation of the premature ejaculation diagnostic tool and its association with intravaginal ejaculatory latency time

Insight on pathogenesis of lifelong premature ejaculation: inverse relationship between lifelong premature ejaculation and obesity

Impact of erectile function and age in men with lower urinary tract symptoms on ejaculatory dysfunction and premature ejaculation

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