Clinicians can easily miss the importance of how what is not present gives depth, perspective, and clues to the real meaning of social action in clinical encounters. This essay addresses examples of commonly overlooked forms of this concept of negative space in the clinician-patient relationship. The examples are negative physical space, which denotes the physical distances that separate clinicians and patients during face-to-face encounters; negative communicative space, which refers to how nonverbal and verbal communication can signify information not exchanged during these visits; and negative longitudinal space, which describes pauses over time and includes what is not said between clinicians and patients between visits. Discussed is how the awareness of these different spaces helps us to let go of our preconceptions, to experience what is there rather than what we expect to fi nd, and to use space sensitively to improve interactions with patients. A rt provides lessons that are relevant to family practice and include the need to look closely without preconceptions.1 Close observation is important because there is a common tendency to focus on positive space, which is the space occupied by subjects. It is easy to miss the negative space, which in art is the space between or around subjects. Art teaches us that if we ignore the negative space, we risk seeing only the positive space we expect to see, rather than what is there. Awareness of negative space enables us to let go of our presumptions and be open to new possibilities. For example, a well-known illustration of negative space is shown in Figure 1; which fi rst reveals a vase but, on refl ection, also depicts 2 faces in profi le.The concept of negative space signifi es in medicine what is not seen, not heard, not felt, or otherwise not done or experienced. Negative space frames and provides context for what is present, for example, during clinician-patient interactions. The context of these interactions is incomplete without alertness to negative space, because in the practice of medicine clinicians can easily fail to notice-and be responsive to-what is absent in perceiving what is at hand.As health professionals, we need to be aware of what is not, in the midst of what is, so we can move beyond what we expect, or take for granted, in interpreting the positive spaces that clinicians and patients occupy. This essay focuses on the concept of negative space in clinicianpatient interactions. Specifi cally, it considers 3 neglected forms of negative space in these encounters: (1) negative physical space, which denotes the physical distances that separate the clinician and patient during their face-to-face encounters; (2) negative communicative space, which refers to how nonverbal and verbal communication can each signify information not exchanged during these visits; and (3) do not say to each other between visits. I discuss how our alertness to, understanding of, and sensitive use of these different spaces can improve the delivery of clinical care ...