An Evidence-Based Systematic Review of Cinnamon (<i>Cinnamomum</i>spp.) by the Natural Standard Research Collaboration

Ulbricht, Catherine; Seamon, Erica; Windsor, Regina C.; Armbruester, Nicole; Bryan, J. Kathryn; Costa, Dawn; Giese, Nicole; Gruenwald, Joerg; Iovin, Ramon; Isaac, Richard; Serrano, Jill M. Grimes; Tanguay-Colucci, Shaina; Weissner, Wendy; Yoon, Heeja; Zhang, Jie

doi:10.3109/19390211.2011.627783

Cited by 51 publications

(39 citation statements)

References 449 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Activation of various isoforms lowers levels of plasma triglycerides, elevates levels of HDL-C, and increases insulin sensitivity. 3 Glucose transport by the glucose transporters (GLUT), more specifically GLUT4, is also a primary target of diabetes research. Current research suggests that facilitating translocation through GLUT4 will increase glucose uptake and utilization, benefitting hyperglycemic control.…”

Section: Discussionmentioning

confidence: 99%

“…2 These possible effects may be a concern for patients with impaired liver function, concurrent anticoagulant or antiplatelet therapy, patients on antilipidemic agents, and those who are known to be hypersensitive to cinnamon or its components. There are reports of nonimmunologic contact urticaria occurring in people coming into contact with cinnamon products 3 ; however, because no human studies have been conducted to test this theory, these concerns remain hypothetical. Although our meta-analysis did not address safety data because the reporting of adverse events and tolerability were not consistent among the RCTs, all the included trials stated that no significant side effects were seen with cinnamon use.…”

Section: Discussionmentioning

confidence: 99%

“…It has been suggested that the modality in which cinnamon expresses its effect on blood glucose can be attributed to its active component cinnamaldehyde. 3 The insulinotropic effects of cinnnamaldehyde have been preliminarily investigated and are thought to…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis

Allen

Schwartzman

Baker

et al. 2013

The Annals of Family Medicine

216

131

View full text Add to dashboard Cite

PURPOSE Cinnamon has been studied in randomized controlled trials (RCTs) for its glycemic-lowering effects, but studies have been small and show conflicting results. A prior meta-analysis did not show significant results, but several RCTs have been published since then. We conducted an updated systematic review and meta-analysis of RCTs evaluating cinnamon's effect on glycemia and lipid levels.METHODS MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) were searched through February 2012. Included RCTs evaluated cinnamon compared with control in patients with type 2 diabetes and reported at least one of the following: glycated hemoglobin (A 1c ), fasting plasma glucose, total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), or triglycerides. Weighted mean differences (with 95% confidence intervals) for endpoints were calculated using random-effects models. RESULTSIn a meta-analysis of 10 RCTs (n = 543 patients), cinnamon doses of 120 mg/d to 6 g/d for 4 to 18 weeks reduced levels of fasting plasma glucose (-24.59 mg/dL; 95% CI, -40.52 to -8.67 mg/dL), total cholesterol (-15.60 mg/ dL; 95% CI, -29.76 to -1.44 mg/dL), LDL-C (-9.42 mg/dL; 95% CI, -17.21 to -1.63 mg/dL), and triglycerides (-29.59 mg/dL; 95% CI, -48.27 to -10.91 mg/ dL). Cinnamon also increased levels of HDL-C (1.66 mg/dL; 95% CI, 1.09 to 2.24 mg/dL). No significant effect on hemoglobin A 1c levels (-0.16%; 95%, CI -0.39% to 0.02%) was seen. High degrees of heterogeneity were present for all analyses except HDL-C (I 2 ranging from 66.5% to 94.72%). CONCLUSIONSThe consumption of cinnamon is associated with a statistically significant decrease in levels of fasting plasma glucose, total cholesterol, LDL-C, and triglyceride levels, and an increase in HDL-C levels; however, no significant effect on hemoglobin A 1c was found. The high degree of heterogeneity may limit the ability to apply these results to patient care, because the preferred dose and duration of therapy are unclear.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis

Allen

Schwartzman

Baker

et al. 2013

The Annals of Family Medicine

216

131

View full text Add to dashboard Cite

show abstract

“…Cinnamon (Cinnamomum cassia) has become a natural product of interest because it has been hypothesized to provide health benefits, for example the ability to reduce blood glucose and levels of serum lipids. It has been suggested that the effect of cinnamon on blood glucose can be attributed to its active component cinnamaldehyde [9]. Cinnamon has been of research interest for patients with diabetes since the 1990s, when peroxisome proliferator-activated receptors (PPARs) were recognized as a possible therapeutic target for diabetes and dyslipidemia [10].…”

Section: T2dmmentioning

confidence: 99%

Effect of cinnamon supplementation on glucose, lipids levels, glomerular filtration rate, and blood pressure of subjects with type 2 diabetes mellitus

Sengsuk

Sanguanwong²,

Tangvarasittichai

et al. 2015

Diabetol Int

View full text Add to dashboard Cite

A randomized, double-blind, placebo-controlled trial was performed to investigate the effect of cinnamon supplementation on glucose, triglyceride (TG), and high density lipoprotein-cholesterol (HDL-C) levels, TG/HDL-C ratio, blood pressure (BP), and estimated glomerular filtration rate (eGFR) for ninety-nine type 2 diabetes mellitus (T2DM) patients. Forty nine (49) patients with T2DM were in the cinnamon group whereas 50 were in the placebo group. All participants received either a cinnamon or placebo capsule daily for the 60-day study period. At the end of the study, median glucose, TG, TG/HDL-C ratio, and BP were significantly decreased (p \ 0.005) whereas HDL-C and eGFR levels were significantly increased (p \ 0.005) in the cinnamon supplementation group. Interestingly, the study also revealed reduction of HbA1c levels after the 60-day study period. In the placebo group, glucose, TG levels tended to increase and HDL-C levels tended to decrease whereas systolic and diastolic BP, HbA1c, and BUN CT were significantly increased and eGFR was significantly reduced (p \ 0.005). Cinnamon supplementation reduced plasma glucose, HbA1c, triglyceride, TG/HDL-C ratio, and BP and increased HDL-C levels and eGFR in subjects with T2DM. Cinnamon supplementation may be beneficial for those with T2DM to prevent and control diabetic complications.

show abstract

“…Therefore, it was used to treat dry and itchy throat, productive cough, thirst, aphonia, dysuria, and interference of defecation [33]. The tongue grass moisturized the tissues and was anti-inflammatory, relieving cough and asthma [34]. The maidenhair fern possessed the functions of anti-inflammation and detoxification, relieving cough and eliminating phlegm, mitigating asthma and pain.…”

Section: Discussionmentioning

confidence: 99%

Effect of Abnormal Savda Munziq, a Traditional Uighur Herbal Medicine, on Pulmonary Function and Aquaporins of COPD Rat Model with Abnormal Savda Syndrome

Gao

Upur

Wang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Objective To investigate the effect of abnormal savda munziq (ASM) on the pulmonary function and expression of lung-specific aquaporins in the rat model of chronic obstructive pulmonary disease with abnormal savda syndrome (ASSCOPD). Methods Eighty male rats were randomized into ASSCOPD, COPD, and control groups. ASSCOPD was further categorized into ASM and non-ASM groups. COPD model was established by combining fumigation with airway instillation of elastase; ASSCOPD model was developed based on COPD by induction with dry cold diet, cold dry environment, and plantar electric stimulation. ASM was administered twice daily. The pulmonary function was evaluated based on respiration. The mRNA and protein levels of AQPs were estimated by real-time PCR and Western blot, respectively. Results MV, TV, the mRNA level of AQP5, and the protein expression of AQP1, AQP4, and AQP5 were increased in ASMCOPD compared to ASSCOPD. Conclusion The pulmonary function was impaired in ASSCOPD group; the expression of AQP1, AQP4, and AQP5 was decreased at protein and mRNA levels in ASSCOPD group. ASM can improve the pulmonary function in ASSCOPD for MV and TV. ASM could elevate the protein expression of AQP1, AQP4, and AQP5 and the mRNA level of AQP5 in lung tissue.

show abstract

An Evidence-Based Systematic Review of Cinnamon (Cinnamomumspp.) by the Natural Standard Research Collaboration

Cited by 51 publications

References 449 publications

Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis

Cinnamon Use in Type 2 Diabetes: An Updated Systematic Review and Meta-Analysis

Effect of cinnamon supplementation on glucose, lipids levels, glomerular filtration rate, and blood pressure of subjects with type 2 diabetes mellitus

Effect of Abnormal Savda Munziq, a Traditional Uighur Herbal Medicine, on Pulmonary Function and Aquaporins of COPD Rat Model with Abnormal Savda Syndrome

Contact Info

Product

Resources

About