This study investigated the weakening model, law of mechanics parameters, and stability of the sliding zone soil associated with thrust-load-induced accumulation landslides triggered by rainfall infiltration. The spatial and morphological characteristics and rule of the sapping process were analyzed, considering the constitutive equation of the sliding zone soil, in order to establish a state curve equation for the weakening coefficient of sliding zone soil based on the “S”-shaped curve. Moreover, a formula for calculating slope stability with this failure mode was derived and applied to calculate the stability of a deformation body in Danbo reservoir, China. The results show that the sliding zone in this type of landslide exhibits steep upward and slow downward trends, and affected by rainfall infiltration, its failure develops gradually from the trailing edge to the front edge. In the constitutive equation, the weakening of soil mechanical parameters is manifested as the weakening of shear stiffness, while the “S”-shaped curve of the weakening coefficient reflects the spatial characteristics of the weakening process. The main factors affecting the accuracy of the slope stability calculation are the values of model parameters and assessment of the development characteristics and weakening stage of the sliding zone.