2012
DOI: 10.1016/j.peptides.2011.11.004
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An evolutionary comparison of leucine-rich repeat containing G protein-coupled receptors reveals a novel LGR subtype

Abstract: Leucine-rich repeat containing G protein-coupled receptors or LGRs are receptors with important functions in development and reproduction. Belonging to this evolutionarily conserved group of receptors are the well-studied glycoprotein hormone receptors and relaxin receptors in mammals, as well as the bursicon receptor, which triggers cuticle hardening and tanning in freshly enclosed insects. In this study, the numerous LGR sequences in different animal phyla are analyzed and compared. Based on these data a phy… Show more

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Cited by 71 publications
(67 citation statements)
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“…The relaxin receptor Lgr3 mediates Dilp8-induced homeostatic control Dilp8 bears homology to the human relaxin peptides (12,25,26). Therefore, we investigated the role for the two fly relaxin receptors encoded by the orphan leucine-rich repeatcontaining G-protein coupled receptors (LGRs), Lgr3 (CG31096) and Lgr4 (CG34411) (27).…”
Section: Resultsmentioning
confidence: 99%
“…The relaxin receptor Lgr3 mediates Dilp8-induced homeostatic control Dilp8 bears homology to the human relaxin peptides (12,25,26). Therefore, we investigated the role for the two fly relaxin receptors encoded by the orphan leucine-rich repeatcontaining G-protein coupled receptors (LGRs), Lgr3 (CG31096) and Lgr4 (CG34411) (27).…”
Section: Resultsmentioning
confidence: 99%
“…This LRR region is flanked by N-terminal and C-terminal cap modules. The eight LGRs can be further subdivided into class A, B, and C receptors (Van Loy et al 2008;Van Hiel et al 2012). A-type receptors contain seven to nine LRRs and a long Hinge region connecting the LRR region with the 7TM domain.…”
Section: Lgr5 Marks Intestinal Stem Cellsmentioning
confidence: 99%
“…The Lgr family proteins can be subdivided into three main groups (A, B and C), according to the relative abundance of LRRs within their ectodomain, together with the presence or absence of a low-density lipoprotein receptor class A domain (LDLa) and the structure of a hinge region connecting the 7TM region to the LRR domain (Kajava, 1998;Van Hiel et al, 2012) (Fig. 1B).…”
Section: Introductionmentioning
confidence: 99%
“…It was first identified as a highly related subclass of the glycoprotein hormone receptor GPCR family during EST database homology searches in the late 1990s (Hsu et al, 2000;Hsu et al, 1998;McDonald et al, 1998). Subsequent phylogenetic analyses revealed the existence of Lgr4-6 homologs throughout the entire animal kingdom, including ancient life forms such as Cnidaria and Placozoa (Luo and Hsueh, 2006;Van Hiel et al, 2012). This reflects both their common ancient origins and their likely functional importance.…”
Section: Introductionmentioning
confidence: 99%