2012
DOI: 10.1038/cr.2012.14
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An evolving picture of the interactions between malaria parasites and their host erythrocytes

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Cited by 4 publications
(2 citation statements)
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“…These findings are consistent with the observation that neuraminidase treatment of recombinant basigin or obliteration of its glycosylation motifs does not affect binding to PfRH5 from 3D7 parasites [37] (PfRH5 from 3D7 and 7G8 both contain the 204I residue [23]). Although the mutant 204K or 204R forms of PfRH5 expressed by LC12 and other A. nancymaae -invasive parasites remain to be tested for basigin binding ability, unsuccessful efforts in two laboratories to knock-out the PfRH5 gene from P. falciparum [23, 37], and the ability of LC12 to invade neuraminidase-treated human erythrocytes despite loss of PfRH5 binding in erythrocyte binding assays, support suggestions that the PfRH5-PfRipr complex may serve in an important role apart from or in addition to a mechanical attachment function [40, 57]. …”
Section: Discussionmentioning
confidence: 99%
“…These findings are consistent with the observation that neuraminidase treatment of recombinant basigin or obliteration of its glycosylation motifs does not affect binding to PfRH5 from 3D7 parasites [37] (PfRH5 from 3D7 and 7G8 both contain the 204I residue [23]). Although the mutant 204K or 204R forms of PfRH5 expressed by LC12 and other A. nancymaae -invasive parasites remain to be tested for basigin binding ability, unsuccessful efforts in two laboratories to knock-out the PfRH5 gene from P. falciparum [23, 37], and the ability of LC12 to invade neuraminidase-treated human erythrocytes despite loss of PfRH5 binding in erythrocyte binding assays, support suggestions that the PfRH5-PfRipr complex may serve in an important role apart from or in addition to a mechanical attachment function [40, 57]. …”
Section: Discussionmentioning
confidence: 99%
“…This EBL family of protein is also known as the duffy binding (DBL) protein family. In P. falciparum, members of these families are termed PfEBL (P. falciparum erythrocyte bindinglike) and PfRH (P. falciparum reticulocyte binding-like homolog) proteins [13,14].…”
Section: Introductionmentioning
confidence: 99%