Flexural vibration of a clamped—clamped, three-layer, one-span sandwich, unidirectional structure composed of isotropic layers is considered in the article. A new single series model of the 2D problem, obtained within the local theory of linear elastodynamics, is presented. Very realistic boundary conditions at edges of the structure, which correspond to the engineering solution with the edge stiffeners, are introduced and satisfied. Eight eigenfrequencies of the structure for two sets of input data are calculated, according to the new model, and compared with numerical and experimental results existing in the literature. A detail comparative analysis of the results is done and some conclusions are presented.