An Exaggerated Blood Pressure Response to Exercise Is Common in the Subacute Phase After Stroke, but Is Not Affected by Randomization to 12 Weeks of Intensive Aerobic Exercise

Sandberg, Keisha R.; Wijkman, Magnus; Kleist, Marie; Falk, Lisa; Enthoven, Paul

doi:10.1097/01.hjh.0000539231.03523.01

Cited by 1 publication

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“…An amplified blood pressure response during exercise is predictive of hypertension (Singh et al., 1999), cerebrovascular and cardiovascular events (Allison et al., 1999; Schultz et al., 2017), and mortality (Mundal et al., 1996). Individuals at risk or with chronic medical conditions such as a history of CVD (Sandberg et al., 2018), hypertension (Sausen et al., 2009), chronic kidney disease (Downey et al., 2017), metabolic syndrome (Miyai et al., 2013) and diabetes (Karavelioglu et al., 2013) have shown an amplified exercise‐induced MAP response thought to be related to increased sympathetic activity and vascular dysfunction (Teixeira & Vianna, 2022). The current study deviates from these findings as the PTSD group did not display significantly elevated MAP responses to exercise when compared to controls.…”

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confidence: 99%

Lower vascular conductance responses to handgrip exercise are improved following acute antioxidant supplementation in young individuals with post‐traumatic stress disorder

Weggen,

Darling,

Autler

et al. 2024

Experimental Physiology

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Young individuals with post‐traumatic stress disorder (PTSD) display peripheral vascular and autonomic nervous system dysfunction, two factors potentially stemming from a redox imbalance. It is currently unclear if these aforementioned factors, observed at rest, alter peripheral haemodynamic responses to exercise in this population. This study examined haemodynamic responses to handgrip exercise in young individuals with PTSD following acute antioxidant (AO) supplementation. Thirteen young individuals with PTSD (age 23 ± 3 years), and 13 age‐ and sex‐matched controls (CTRL) participated in the study. Exercise‐induced changes to arm blood flow (BF), mean arterial pressure (MAP) and vascular conductance (VC) were evaluated across two workloads of rhythmic handgrip exercise (3 and 6 kg). The PTSD group participated in two visits, consuming either a placebo (PL) or AO prior to their visits. The PTSD group demonstrated significantly lower VC (P = 0.04) across all exercise workloads (vs. CTRL), which was significantly improved following AO supplementation. In the PTSD group, AO supplementation improved VC in participants possessing the lowest VC responses to handgrip exercise, with AO supplementation significantly improving VC responses (3 and 6 kg: P < 0.01) by blunting elevated exercise‐induced MAP responses (3 kg: P = 0.01; 6 kg: P < 0.01). Lower VC responses during handgrip exercise were improved following AO supplementation in young individuals with PTSD. AO supplementation was associated with a blunting of exercise‐induced MAP responses in individuals with PTSD displaying elevated MAP responses. This study revealed that young individuals with PTSD exhibit abnormal, peripherally mediated exercise responses that may be linked to a redox imbalance.

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