An examination of the effects of nucleus accumbens core nociceptin on appetitive and consummatory motivation for food

Wilson, Lindsey; Klausner, McKenna; Chuang, Stacey; Patel, Smruti; Pratt, Wayne E.

doi:10.1016/j.bbr.2024.114895

Cited by 1 publication

(1 citation statement)

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“…Studies of dorsal striatal dopamine release following activation or blockade of NOP receptors in SNc highlighted bidirectional modulation of dopamine (Marti et al 2004, Murphy and Maidment 1999, Olianas et al 2008) In the nucleus accumbens, N/OFQ infusion has been shown to reduce dopamine release (Koizumi et al 2004, Murphy and Maidment 1999), and inhibit dopamine synthesis at DA nerve terminals in the NAc by reducing tyrosine hydroxylase phosphorylation (Olianas et al 2008). With regard to behavioral function, N/OFQ infusion into the NAc core of rats reduces their motivation to pursue high-effort palatable food when a less palatable option is freely available (Wilson et al 2024). Intracerebroventricular injection of N/OFQ also attenuates cocaine-induced increases to both locomotion and extracellular dopamine in the NAc (Lutfy et al 2001).…”

Section: Introductionmentioning

confidence: 99%

Developmental and adult striatal patterning of nociceptin ligand marks striosomal population with direct dopamine projections

Hueske,

Stine,

Yoshida

et al. 2024

Preprint

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Circuit influences on the midbrain dopamine system are crucial to adaptive behavior and cognition. Recent developments in the study of neuropeptide systems have enabled high-resolution investigations of the intersection of neuromodulatory signals with basal ganglia circuitry, identifying the nociceptin/orphanin FQ (N/OFQ) endogenous opioid peptide system as a prospective regulator of striatal dopamine signaling. Using a prepronociceptin-Cre reporter mouse line, we characterized highly selective striosomal patterning ofPnocmRNA expression in mouse dorsal striatum, reflecting early developmental expression ofPnoc. In the ventral striatum,Pnocexpression was clustered across the nucleus accumbens core and medial shell, including in adult striatum. We found that PnoctdTomatoreporter cells largely comprise a population of dopamine receptor D1 (Drd1) expressing medium spiny projection neurons localized in dorsal striosomes, known to be unique among striatal projections neurons for their direct innervation of midbrain dopamine neurons. These findings provide new understanding of the intersection of the N/OFQ system among basal ganglia circuits with particular implications for developmental regulation or wiring of striato-nigral circuits.

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