An examination of the physical properties of pure magnesium stearate

Physical characterization of the polymorphic variations of magnesium stearate and magnesium palmitate hydrate species

“…Finally, the trihydrate phases were obtained by quantitative conversion of the anhydrous form upon exposure to relative humidities above 50%. These methods of phase conversion are equivalent to those used by Ertel and Carstensen [11] to produce the same range of hydrate materials.…”

“…Although numerous studies have been conducted which sought to develop a relationship between structure and function, none of these has developed a satisfactory relation [4][5][6][7]. It has been found, however, that the lubricating ability of magnesium stearate is directly affected by its moisture content [8], which has been in turn related to the ability of this compound to form species of differing hydration states [9], This has prompted various workers to study the polymorphism associated with the magnesium stearate hydrate species [10][11][12][13]. To avoid complications of chemical composition, most of these works focused solely on the hydrates of palmitate-free magnesium stearate.…”

Compatibility studies between piroxicam and pharmaceutical excipients used in solid dosage forms

“…This same behavior was described in the literature for mixtures of PVP with other drugs such as naproxen, ibuprofen, and cetoprofen, indicating the occurrence of a strong solid-solid interaction with heating. However, this characteristic does not indicate an incompatibility between the piroxicam and PVP, which can be explained by the dissolution of the drug in PVP [20].…”

Influence of hydration state and homologue composition of magnesium stearate on the physical chemical properties of liquid paraffin lipogels

“…Transformation from one polymorphic form to another during processing can affect the physical chemical properties of the dosage form (Miller and York, 1985;Ertel and Carstensen, 1988;Rajala and Laine, 1995). Magnesium stearate (MgSt) exists as polymorphs and may be composed of either pure or mixed homologues.…”