This study investigates the crucial role of academic qualifications and professional training in enhancing procurement staff performance at Morogoro Referral Hospital, focusing on their impact across various procurement activities. The study utilizes a mixed research approach and a case study research design. The target population of the study comprised of individuals who are involved in procurement activities at Morogoro Referral Hospital. The sample size was 67 respondents selected through convenience and purposive sampling techniques. Data were collected by using questionnaire and interviews. Quantitative data were analyzed using descriptive statistics, while qualitative data is examined through thematic analysis. The study highlights the essential role of academic qualifications and professional training in boosting procurement staff performance, noting broad agreement on their benefits for foundational knowledge and critical skills such as supply chain management and negotiation. Despite varying levels of agreement on areas like supplier evaluation and risk mitigation, the overall positive impact is clear. It is recommended that organizations invest in targeted training programs to address performance gaps, particularly in risk mitigation and supplier evaluation, and ensure ongoing updates to keep staff current with regulations, technology, and best practices. This approach will enhance procurement efficiency and effectiveness, supporting organizational success.