An excellent nanofibrous matrix based on gum tragacanth-poly (Ɛ-caprolactone)-poly (vinyl alcohol) for application in diabetic wound healing

Mohammadi, Marziyeh; Kargozar, Saeid; Bahrami, S. Hajir; Rabbani, Shahram

doi:10.1016/j.polymdegradstab.2020.109105

Cited by 49 publications

(12 citation statements)

References 46 publications

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“…Finally, they were dehydrated using acetone series (30, 50, 75 and 100%), dried in a freeze‐drying (BOC Edwards, Crawley, UK) at −80°C for 6 hours. The samples were kept dry with silica gel until analyzed by SEM 8,19 …”

Section: Methodsmentioning

confidence: 99%

Implementing Taguchi method to analyze electrospinning parameters influence on Mg‐doped fluorapatite nanoparticles‐poly (ε‐caprolactone) nanocomposite scaffold (Mg‐FA NPs/PCL) properties

Fereshteh

Fathi

Kargozar

et al. 2020

Polymers for Advanced Techs

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The present study focused on an investigation of significant electrospinning parameters on Mg-doped fluorapatite nanoparticles-poly (ε-caprolactone) fibrous nanocomposite scaffold (Mg-FA NPs/PCL). Since there are many factors that could have an influence on electrospinning process, Taguchi experimental design approach was used to reduce the number of experiments. The selected parameters included the concentration of polymer, solvent system, ceramic concentration, applied voltage, and the distance between nozzle and collector. The analysis of variance (ANOVA) showed that, among the studied parameters, polymer concentration and type of solvent had the most significant effect on the consistency of the solution which played a major role in producing uniform non-beaded fibers. In order to maximize performance of electrospun scaffold, the surface tension should be kept minimizing by decreasing concentration, applying a high dielectric solvent system, increasing voltage, and declining distance in a very stable electrical field. Eventually, the optimum condition to fabricate Mg-FA NPs/PCL fibrous scaffold was electrospinning 10 wt% PCL with 1 wt% Mg-FA NPs solution in chloroform by applying 20 kV into 20 cm distance. According to the bioactivity and cell attachment results, the electrospun Mg-FA NPs/PCL is suggested as a promising candidate for tissue engineering, especially for bone tissue. K E Y W O R D S biological properties, electrospinning parameters, nanoparticles, Taguchi method, tissue engineering 1 | INTRODUCTION Recently, electrospinning has been applied as an appropriate and effective technique to produce biomimetic nanofibrous scaffolds consisting of a vast web of interconnected fibers and pores. 1-4 The structure of bone extracellular matrix (ECM) includes a fibrous collagen with homogeneously dispersed hydroxyapatite (HA) nanocrystals, therefore, applying electrospun scaffolds for bone tissue engineering has interestingly been increased. A numerous polymers have been employed to engineer the ECM tissues including either as natural polymers such as collagen, gelatin, chitosanor as synthetic polymers for example poly (lactic acid) (PLA), poly (lactide-co-glycolide) (PLGA), poly (glycolic acid) (PGA), polyurethane (PU), poly (ethylene glycol) diacrylate (PEGDA), and poly (ε-caprolactone) (PCL). 1-3,5-9 Owing to the appropriate mechanical properties and controllable degradation rate of synthetic polymers, researchers are extensively interested in

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Section: Methodsmentioning

confidence: 99%

Implementing Taguchi method to analyze electrospinning parameters influence on Mg‐doped fluorapatite nanoparticles‐poly (ε‐caprolactone) nanocomposite scaffold (Mg‐FA NPs/PCL) properties

Fereshteh

Fathi

Kargozar

et al. 2020

Polymers for Advanced Techs

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“…The nanofibers produced using the electrospinning technique have recently been extensively studied in vitro as well as in vivo as a wound‐healing material (Table 4). After the MEN materials have been designed and assessed for the promotion of cell migration and/or multilayered growth factor delivery in vitro , they are tested in vivo using rabbit, 133 rat, 119 or mouse 120 models to evaluate them for wound healing application.…”

Section: In Vitro and In Vivo Advancements Of Nanofibers In Wound Healing Applicationsmentioning

confidence: 99%

In vitro and in vivo advancement of multifunctional electrospun nanofiber scaffolds in wound healing applications: Innovative nanofiber designs, stem cell approaches, and future perspectives

Behere

Ingavle

2021

J Biomedical Materials Res

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The skin is one of the most essential tissues in the human body, interacting with the outside environment and shielding the body from diseases and excessive water loss. Hydrogels, decellularized porcine dermal matrix, and lyophilized polymer scaffolds have all been used in studies of skin wound repair, wound dressing, and skin tissue engineering, however, these materials cannot replicate the nanofibrous architecture of the skin's native extracellular matrix (ECM). Electrospun nanofibers are a fascinating new form of nanomaterials with tremendous potential across a broad spectrum of applications in the biomedical field, including wound dressings, wound healing scaffolds, regenerative medicine, bioengineering of skin tissue, and multifaceted drug delivery. This article reviews recent in vitro and in vivo developments in multifunctional electrospun nanofibers (MENs) for wound healing. This review begins with an introduction to the electrospinning process, its principle, and the processing parameters which have a significant impact on the nanofiber properties. It then discusses the various geometries and advantages of MEN scaffolds produced by different innovative electrospinning techniques for wound healing applications when used in combination with stem cells. This review also discusses some of the possible future nanofiber‐based models that could be used. Finally, we conclude with potential perspectives and conclusions in this area.

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“…Histological analyses of mats holding stem cells into diabetic rats displayed tissue healing and regeneration consisting of re-epithelization and collagen formation within 15 days. Finally, the authors concluded that made-up NFs with remarkable mechanical and biological characteristics are promising scaffolds in wound healing of diabetic ulcers [152].…”

Section: Pva-pcl Matsmentioning

confidence: 99%

Nanofiber-based systems intended for diabetes

et al. 2021

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Diabetic mellitus (DM) is the most communal metabolic disease resulting from a defect in insulin secretion, causing hyperglycemia by promoting the progressive destruction of pancreatic β cells. This autoimmune disease causes many severe disorders leading to organ failure, lower extremity amputations, and ultimately death. Modern delivery systems e.g., nanofiber (NF)-based systems fabricated by natural and synthetic or both materials to deliver therapeutics agents and cells, could be the harbinger of a new era to obviate DM complications. Such delivery systems can effectively deliver macromolecules (insulin) and small molecules. Besides, NF scaffolds can provide an ideal microenvironment to cell therapy for pancreatic β cell transplantation and pancreatic tissue engineering. Numerous studies indicated the potential usage of therapeutics/cells-incorporated NF mats to proliferate/regenerate/remodeling the structural and functional properties of diabetic skin ulcers. Thus, we intended to discuss the aforementioned features of the NF system for DM complications in detail. Graphic abstract

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An excellent nanofibrous matrix based on gum tragacanth-poly (Ɛ-caprolactone)-poly (vinyl alcohol) for application in diabetic wound healing

Cited by 49 publications

References 46 publications

Implementing Taguchi method to analyze electrospinning parameters influence on Mg‐doped fluorapatite nanoparticles‐poly (ε‐caprolactone) nanocomposite scaffold (Mg‐FA NPs/PCL) properties

Implementing Taguchi method to analyze electrospinning parameters influence on Mg‐doped fluorapatite nanoparticles‐poly (ε‐caprolactone) nanocomposite scaffold (Mg‐FA NPs/PCL) properties

In vitro and in vivo advancement of multifunctional electrospun nanofiber scaffolds in wound healing applications: Innovative nanofiber designs, stem cell approaches, and future perspectives

Nanofiber-based systems intended for diabetes

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