An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding

Sweeney, Patrick J.; Yang, Yunlei

doi:10.1038/ncomms10188

Cited by 125 publications

(139 citation statements)

References 56 publications

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“…As noted previously, hippocampal damage impairs the ability of rats to use cues arising from their deprivation state as discriminative stimuli, and Experiment 3 confirmed previous findings that interference with hippocampal functioning is associated with reduced control of energy intake and body weight regulation. In addition, new findings have identified an excitatory neural pathway from the ventral hippocampus to the lateral septum that suppresses food intake [37]. Furthermore, Kanoski and his colleagues demonstrated ventral hippocampal regulation of feeding through activations of anorectic (leptin [38]; GLP-1 [39]) and orexigenic (ghrelin [40]) signaling pathways.…”

Section: Discussionmentioning

confidence: 99%

Western diet and the weakening of the interoceptive stimulus control of appetitive behavior

Sample

Jones

Hargrave

et al. 2016

Behavioural Brain Research

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In obesogenic environments food-related external cues are thought to overwhelm internal cues that normally regulate energy intake. We investigated how this shift from external to internal stimulus control might occur. Experiment 1 showed that rats could use stimuli arising from 0 and 4h food deprivation to predict sucrose delivery. Experiment 2 then examined (a) the ability of these deprivation cues to compete with external cues and (b) how consuming a Western-style diet (WD) affects that competition. Rats were trained to use both their deprivation cues and external cues as compound discriminative stimuli. Half of the rats were then placed on WD while the others remained on chow, and external cues were removed to assess learning about deprivation state cues. When tested with external cues removed, chow-fed rats continued to discriminate using only deprivation cues, while WD-fed rats did not. The WD-fed group performed similarly to control groups trained with a noncontingent relationship between deprivation cues and sucrose reinforcement. Previous studies provided evidence that discrimination based on interoceptive deprivation cues depends on the hippocampus and that WD intake could interfere with hippocampal functioning. A third experiment assessed the effects of neurotoxic hippocampal lesions on weight gain and on sensitivity to the appetite-suppressing effects of the satiety hormone cholecystokinin (CCK). Relative to controls, hippocampal-lesioned rats gained more weight and showed reduced sensitivity to a 1.0 ug but not 2.0 or 4.0 ug CCK doses. These findings suggest that WD intake reduces utilization of interoceptive energy state signals to regulate appetitive behavior via a mechanism that involves the hippocampus.

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Section: Discussionmentioning

confidence: 99%

Western diet and the weakening of the interoceptive stimulus control of appetitive behavior

Sample

Jones

Hargrave

et al. 2016

Behavioural Brain Research

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“…Further anterograde track tracing and immunohistological approaches determined that vHPC GHSR neurons project to LH orexin neurons and pharmacological blockage of this projection pathway blocked the orexigenic effect of vHPC ghrelin signaling in conditioned feeding responses [60]. While these findings are interesting, the precise neural circuits connecting vHPC ghrelin neurons to orexin neurons in the LH remain to be determined as vHPC projects directly to LH as well as indirectly through NAc, BNST, and LS [54, 56, 65]. Furthermore, given that ventral hippocampal leptin and GLP-1 signaling have been reported to decrease feeding behavior [57, 58], additional work is needed to determine the downstream neural circuits connecting hippocampal leptin and GLP-1 signaling to primary feeding circuitry in the hypothalamus or elsewhere.…”

Section: Newly-identified Hippocampal and Amygdala Feeding Circuitsmentioning

confidence: 99%

Neural Circuit Mechanisms Underlying Emotional Regulation of Homeostatic Feeding

Sweeney

Yang

2017

Trends in Endocrinology & Metabolism

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The neural circuits controlling feeding and emotional behaviors are intricately and reciprocally connected. Recent technological developments, including cell type-specific optogenetic and chemogenetic approaches, allow for functional characterization of genetically-defined cell populations and neural circuits in feeding and emotional processes. Here, we review recent studies that have utilized circuit-based manipulations to decipher the functional interactions between neural circuits controlling feeding and those controlling emotional processes. Specifically, we highlight newly-described neural circuit interactions between classical emotion-related brain regions, such as hippocampus and amygdala, and homeostatic feeding circuitry in the arcuate nucleus and lateral hypothalamus. Together, these circuits will provide a template for future studies to examine functional interactions between feeding and emotion.

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“…First, following hippocampal lesions, this ability is impaired (e.g., [62]). Second, Sweeney & Yang [164] have identified a likely brain substrate (i.e., glutamatergic projections from the ventral hippocampus to the lateral septum) for this type of inhibitory control. Coincidentally, the ventral hippocampus is a key substrate for inhibitory control of approach tendencies within approach-avoidance paradigms [145].…”

Section: Hippocampus and Inhibitory Processes Related To Food Intakementioning

confidence: 99%

The anterior medial temporal lobes: Their role in food intake and body weight regulation

Coppin

2016

Physiology & Behavior

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• The amygdala and hippocampus play a major role in food intake and weight regulation.• These functions are far less known to cognitive and affective scientists.• This review uniquely expands on the interactions between these two brain structures. a b s t r a c t a r t i c l e i n f o The anterior medial temporal lobes are one of the most studied parts of the brain. Classically, their two main structures -the amygdalae and the hippocampi -have been linked to key cognitive and affective functions, related in particular to learning and memory. Based on abundant evidence, we will argue for an alternative but complementary point of view: they may also play a major role in food intake and body weight regulation. First, an overview is given of early clinical evidence in this line of thought. Subsequently, empirical evidence is presented on how food intake, including in the extreme case of obesity, may relate to amygdalian and hippocampal functioning. The focus is on the amygdala's role in processing the relevance of food stimuli, cue-induced feeding, and stress-induced eating and on the hippocampus' involvement in the use of interoceptive signals of hunger and satiety, as well as memory and inhibitory processes related to food intake. Additionally, an elaboration takes place on possible reciprocal links between food intake, body weight, and amygdala and hippocampus functioning. Finally, issues that seemed particularly critical for future research in the field are discussed.

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An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding

Cited by 125 publications

References 56 publications

Western diet and the weakening of the interoceptive stimulus control of appetitive behavior

Western diet and the weakening of the interoceptive stimulus control of appetitive behavior

Neural Circuit Mechanisms Underlying Emotional Regulation of Homeostatic Feeding

The anterior medial temporal lobes: Their role in food intake and body weight regulation

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