This chapter describes a design methodology for business processes and workflows that focuses first on "business artifacts", which represent key (real or conceptual) business entities, including both the business-relevant data about them and their macro-level lifecycles. Individual workflow services (a.k.a. tasks) are then incorporated, by specifying how they operate on the artifacts and fit into their lifecycles. The resulting workflow is specified in a particular artifact-centric workflow model, which is introduced using an extended example. At the logical level this workflow model is largely declarative, in contrast with most traditional workflow models which are procedural and/or graph-based. The chapter includes a discussion of how the declarative, artifact-centric workflow specification can be mapped into an optimized physical realization.