An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations

Prajapati, Shiv Kumar; Malaiya, Akanksha; Mishra, Gaurav; Jain, Dolly; Kesharwani, Payal; Mody, Nishi; Ahmadi, Amirhossein; Paliwal, Rishi; Jain, Ankit

doi:10.1016/j.jep.2022.115420

Cited by 25 publications

(12 citation statements)

References 146 publications

(165 reference statements)

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“…The spices and herbs used in the preparation of the Kwath have a variety of the pharmacological effects (Joshi et al, 2017). Some of the attributes which have direct link with the prevention and treatment of the COVID‐19 include anti‐inflammatory, immunomodulatory, anti‐viral, and anti‐pyretic effects (Prajapati et al, 2022). Table 2 presents the summary of the immunomodulatory effects of different components of the Kwath , whereas Table 3 presents the anti‐viral property of different phytochemicals present in Kwath .…”

Section: Pharmacology Of Different Herbs and Spices Used In Kwath Pre...mentioning

confidence: 99%

Culinary spices and herbs in managing early and long‐COVID‐19 complications: A comprehensive review

Sharma

2023

Phytotherapy Research

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Human race is preparing for the upsurge and aftermath of COVID‐19 pandemic complicated by novel variants, new waves, variable mortality rate, and post‐COVID complications. Despite use of repurposed drugs, symptomatic treatments and licensing of multiple vaccines, the daily number of cases and rate of transmission are significant. Culinary spices and herbs have been historically used in pandemic and non‐pandemic times to reduce respiratory viral burden. Specific food items and culinary spices can boost the levels of protective immunity and also offer therapeutic benefits against impervious bugs via well‐known as well as less‐known but scientifically testable mechanisms. Here, we analyzed the phytochemicals profile of Ayurvedic herbs and inferred from the clinical trials/observational studies to provide a focused and succinct perspective on the relevance of “food‐based” traditional decoction to moderate COVID‐19 disease and long‐COVID via modulation of immunity and reinstatement of homeostasis. We also underscore the druggable targets in pathogenesis of COVID‐19 which are relevant to the ongoing clinical trials using spices and herbs. This information will provide a strong scientific rationale for standardization of the traditional herbs‐based therapies and adopting the use of herbs, spices, and their formulations for reducing SARS‐CoV‐2 transmission, long‐COVID symptoms, and COVID‐19 disease progression.

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Section: Pharmacology Of Different Herbs and Spices Used In Kwath Pre...mentioning

confidence: 99%

Culinary spices and herbs in managing early and long‐COVID‐19 complications: A comprehensive review

Sharma

2023

Phytotherapy Research

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“…Another study showed that the citrus flavonoid naringin is able to inhibit ACE2 enzyme, showing very low estimated docking energy (−6.85 kcal/mol) [ 159 ]. Several flavonoids, including apigenin, fisetin, luteolin, kaempferol, jusanin, and quercetin, have been effectively used for the prevention and/or treatment of COVID-19 [ 160 , 161 ] and post-COVID [ 162 , 163 , 164 ].…”

Section: Nutraceuticals and Dietary Supplements Against Covid-19 Dise...mentioning

confidence: 99%

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

Catalano

Iacopetta

Ceramella

et al. 2022

Foods

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The beginning of the end or the end of the beginning? After two years mastered by coronavirus disease 19 (COVID-19) pandemic, we are now witnessing a turnaround. The reduction of severe cases and deaths from COVID-19 led to increasing importance of a new disease called post-COVID syndrome. The term post-COVID is used to indicate permanency of symptoms in patients who have recovered from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Immune, antiviral, antimicrobial therapies, as well as ozone therapy have been used to treat COVID-19 disease. Vaccines have then become available and administered worldwide to prevent the insurgence of the disease. However, the pandemic is not over yet at all given the emergence of new omicron variants. New therapeutic strategies are urgently needed. In this view, great interest was found in nutraceutical products, including vitamins (C, D, and E), minerals (zinc), melatonin, probiotics, flavonoids (quercetin), and curcumin. This review summarizes the role of nutraceuticals in the prevention and/or treatment of COVID-19 disease and post-COVID syndrome.

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“…From long times ago, traditional medicinal plants are consumed globally for the management of different chronic diseases, including arthritis, in developing countries where other medical choices are mostly limited. [11][12][13][14] Along with their direct predictable effects on management of complications associated with knee OA's, plant remedies can also indirectly reduce the side effects associated with conventional therapies by reducing their minimal effective concentrations during concurrent therapy. 15 Ginger officially referred as Zingiber officinale Rosc.…”

Section: What Is Known and Objectivesmentioning

confidence: 99%

A randomized, double‐blind placebo‐controlled phase I clinical study on safety and efficacy of the G‐Rup ® syrup (a mixture of ginger extract and honey) in symptomatic treatment of knee osteoarthritis

Afshar

Abdolahi

Amin

et al. 2022

Clinical Pharmacy Therapeu

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What is known and Objectives Present study evaluated the safety profile and efficacy of G‐Rup® syrup (100 mg/ml ginger extract plus 150 mg/ml honey) in symptomatic treatment of knee osteoarthritis (OA). Methods Patients diagnosed with knee OA were randomly assigned (1:1) to receive either of a 30 ml twice daily regimen of G‐Rup® syrup or placebo over a 12‐week period. Primary endpoints of the study comprised of an improvement in the joint's stiffness, physical functioning and pain score, assessed by WOMAC questionnaire and the visual analog scale (VAS). Secondary objectives comprised of safety and tolerability of the syrup by patients. Results and discussion The 30 ml twice‐daily regimen of G‐Rup® syrup was safe and well tolerated by patients. Moreover, in whole studied time points, treatment with G‐Rup® syrup could significantly Power the VAS score (p < 0.001) whereas improving WOMAC total score (p < 0.001) and pain (p < 0.001), physical functioning (p < 0.001), and stiffness sub‐scores (p = 0.006) compared to the placebo receiving group. What is new and Conclusion Based on obtained results, the G‐Rup® syrup, composed of a combination of honey and ginger, may be a proper supplementary choice, along with routine therapeutic regimens, for improvement of symptomatic treatment of OA.

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An exhaustive comprehension of the role of herbal medicines in Pre- and Post-COVID manifestations

Cited by 25 publications

References 146 publications

Culinary spices and herbs in managing early and long‐COVID‐19 complications: A comprehensive review

Culinary spices and herbs in managing early and long‐COVID‐19 complications: A comprehensive review

Are Nutraceuticals Effective in COVID-19 and Post-COVID Prevention and Treatment?

A randomized, double‐blind placebo‐controlled phase I clinical study on safety and efficacy of the G‐Rup ® syrup (a mixture of ginger extract and honey) in symptomatic treatment of knee osteoarthritis

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