An Expedient Synthesis of Novel Derivatives of Pyrido[2,3‐d]pyrimidines Using Magnetically Supported ZrO₂ Nanocatalyst

Abstract

An efficient synthesis of pyrido[2,3‐d]pyrimidine derivatives via one‐pot multicomponent reactions of 6‐amino‐2‐(alkylthio)pyrimidin‐4(3H)‐one, 3‐cyanoacetylindole and arylaldehydes using [Fe3O4@ZrO2] as magnetically recyclable nanocatalyst is reported. This protocol furnished the desired products in good to excellent yields (70–93 %) and lower reaction times. The catalyst could be easily and efficiently separated from the final product solution by an external magnet and be reused in 5 consecutive runs without any significant activity decrease.

HAp‐encapsulated γ‐Fe2O3‐supported dual acidic heterogeneous catalyst for highly efficient one‐pot synthesis of benzoxanthenones and 3‐pyranylindoles

“…In continuation of our research interests in the application of heterogeneous and ionic liquid catalysts for development of useful synthetic methodologies, in the present article we report the synthesis and application of the novel [Fe 2 O 3 @HAp]‐supported dual acidic nanocatalyst 3 (Scheme ) in efficient, simple and facile one‐pot three‐component syntheses of benzo[ a ]xanthenone and 3‐pyranylindole derivatives (Scheme ).…”

Studies on the Synthesis of Substituted 2-amino-4H-benzo[h]chromene and 3-amino-1H-benzo[f]chromene Derivatives Using Base Supported Ionic Liquid Like-phase (SILLP) as an Efficient Green Catalyst

“…They are the solvents of choice for a large array of organic reactions and can perform as a catalyst at the same time. [16][17][18][19][20][21][22] With respect to our continued interest in developing benign methods for the synthesis of biologically important products, [23][24][25][26][27][28] we report a simple and high-yielding protocol for the synthesis of 2-amino-2-chromenes using SILLP as an efficient and recyclable heterogeneous base catalyst (Scheme 1).…”

Ultrasound‐assisted efficient synthesis of polyfunctional 1,2,4‐triazoles as novel antibacterial and antioxidant agents

“…We recently reported an efficient and ecofriendly procedure for preparing polysubstituted imidazoles. [44] In continuation of our interest in developing benign synthetic routes for the preparation of biologically important heterocycles, [45][46][47][48][49][50] we decided to synthesize some novel imidazole derivatives with a 1,2,4-triazole substituent in the presence of readily available KHSO 4 catalyst in ethanol under ultrasonic irradiation (Scheme 1).…”