An expeditious one-pot synthesis of novel bioactive indole-substituted pyrido[2,3-d]pyrimidines using Fe3O4@SiO2-supported ionic liquid nanocatalyst

An expeditious one-pot synthesis of pyrido[2,3-d]pyrimidines using Fe3O4–ZnO–NH2–PW12O40 nanocatalyst

“…According to the results, using 20 mg Fe 3 O 4 -ZnO-NH 2 -PW 12 O 40 in H 2 O at 80 °C proved to be the best condition for this reaction (Table 1). By performing the reaction in the presence of an acid, a base, and a salt, no improvement was achieved (entries [15][16][17]. In order to show the role of catalyst, similar reaction was performed in the absence of the catalyst.…”

“…13 Among different nanoparticles, magnetite (Fe 3 O 4 ) has been the focus of much attention as an interesting alternative to allow separation of the nanocatalyst from the reaction mixture by means of an external magnetic field. For example, microwaveassisted synthesis of pyrido [2,3-d:6,5-d′]dipyrimidine derivatives using CuFe 2 O 4 nanoparticles in water, 14 synthesis of novel bioactive indole-substituted pyrido [2,3d]pyrimidines using Fe 3 O 4 @SiO 2 -supported ionic liquid nanocatalyst 15 have been reported.…”

Synthetic strategies of heterocycle-integrated pyridopyrimidine scaffolds supported by nano-catalysts

“…The pyridine ring was cyclized through the formation of C-C "involved the arylidene formation", and C-N bonds "involved the intramolecular cyclization". 103 In 2018, Mamaghani et al 104 utilized Fe 3 O 4 @SiO 2 -supported ionic liquid nanocatalyst for the synthesis of alkyl-indolyl pyrido[2,3-d]pyrimidines 34a-j. Thus, one-pot multicomponent reactions of dialkyl amino-uracil with aryl aldehydes and 2methyl-3-cyanoacetylindole under the optimized conditions gave the anticipated products 34a-j.…”

Ag/CuO/MCM-48 AS A POTENTIAL CATALYST FOR THE SYNTHESIS OF SYMMETRICAL AND UNSYMMETRICAL POLYHYDROQUINOLINES

“…As a continuation of our ongoing endeavors in developing novel and practical multicomponent reactions to synthesize heterocyclic compounds of biological importance [37][38][39][40][41][42][43][44][45], we herein present the catalytic efficiency of Ag/CuO/MCM-48 for the multicomponent synthesis of symmetrical and unsymmetrical polyhydroquinoline derivatives under identical reaction conditions (Scheme 1). Recently, unsymmetrical polyhydroquinoline motifs have been recognized as lead molecules in antidiabetic drug discovery [46].…”