An experience of second-trimester anhydramnios salvaged by single amnioinfusion

Abstract

Second-trimester anhydramnios, which is primarily caused by ruptured membranes, placental dysfunction, or congenital renal malformations, is associated with high perinatal morbidity and mortality. Although amnioinfusion temporarily increases amniotic fluid volume, it does not generally provide a fundamental solution. We describe a case of second-trimester anhydramnios with an umbilical cord factor, wherein single amnioinfusion may have successfully broken a vicious circle involving non-reassuring fetal status. A 34-year-old primigravid woman was referred to our hospital because of anhydramnios at 22 weeks' gestation. Single amnioinfusion improved the fetal circulatory failure, and the patient delivered a healthy full-term newborn. Single amnioinfusion may be a therapeutic approach to improve the prognosis of pregnancy when second-trimester anhydramnios results from umbilical cord factors.

Etiology and management of early pregnancy renal anhydramnios: Is there a place for serial amnioinfusions?

“…The association between amniotic fluid and lung development has motivated investigators to attempt serial amnioinfusions in both bilateral renal agenesis and other EPRA‐related conditions . Anecdotal cases where fetuses treated in this fashion survived postnatally and went on to undergo successful dialysis and renal transplant provide a rationale to study amniofusion for this condition, as these successful case reports demonstrate that both short term respiratory survival and long‐term renal survival is possible in EPRA …”