An experimental analysis of interlamellar tight junctions in amphibian and mammalian C.N.S. myelin

Tabira, Takeshi; Mj, Cullen; Pj, Reier; deF, Webster H

doi:10.1007/bf01173993

Cited by 61 publications

(41 citation statements)

References 27 publications

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“…These numerical values in diameter and spacing correspond to those in the dots and lines of the radial component observed in thin sections. These observations indicate that the myelinic tight junction of TABIRA et al (1978) and DERMIETZEL (1974 is in accord with the radial component. However, in the radial component, the arrangement of ridges of particles is linear and a lack of particles is found in the course of the ridges.…”

Section: Discussionsupporting

confidence: 66%

“…In the present study, which used a fixing mixture composed of potassium ferrocyanide, glutaraldehyde and osmium, and an epoxy resin embedding, the radial component appears as rows of electron-lucent dots stunding across the thickness of the myelin sheath. TABIRA et al (1978) show the same light lines for the radial component using a fixative containing osmium ferrocyanide and Durcupan embedding. DERMIETZEL and KROcZEK (1980) also indicate the same electron-lucent lines using a water-miscible embedding medium (GMA).…”

Section: Discussionmentioning

confidence: 99%

“…The concept of a myelinic tight junction in the central and peripheral myelin sheath was proposed by TABIRA et al (1978) and DERMIETZEL (1974 after using freeze-fracture replication. They suggested that the myelinic tight junctions correspond to the radial components described earlier by H0NJIN et al (1959H0NJIN et al ( , 1963H0NJIN et al ( , 1964 and PETERS (1961PETERS ( , 1964PETERS ( , 1968.…”

Section: Discussionmentioning

confidence: 99%

“…TABIRA et al (1978), based on experiments of the frog optic nerve, reported a remarkable resistance of the myelinic tight junction against the vacuolating effect of hexachlorophene (HCP) intoxication. NAGARA et al (1981NAGARA et al ( , 1982 described the myelinic tight junction's role as that of "stopper ," preventing against the myelin spliting induced by triethyl tin (TET) in the spinal ganglia of neurological mutant mice.…”

Section: Discussionmentioning

confidence: 99%

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Ultrastructure of the radial components of the mouse optic nerve and its changes during wallerian degeneration.

Honjin

Yamashita

Higashimoto

et al. 1985

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary. Radial components of the optic nerve of the mouse were studied by using thin sections and freeze-fracture replicas. The investigations were performed on normal optic nerves, as well as on those undergoing Wallerian degeneration following eyeball enucleation. Normal radial components in thin sections were observed as a series of light lines composed of small electron-lucent dots situated in the interperiod lines across the myelin sheath. They are frequently found in those parts of the myelin sheath lying near the outer and inner processes of the oligodendroglia.Radial components in freeze-fracture replica were observed as a parallel array of many ridges composed of a row of particles.The particles of radial components located in the deeper part of the myelin sheath lose their linear arrangement and fall into disorder in a relatively early post-operative period.

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Section: Discussionsupporting

confidence: 66%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Ultrastructure of the radial components of the mouse optic nerve and its changes during wallerian degeneration.

Honjin

Yamashita

Higashimoto

et al. 1985

Arch. Histol. Jap., Arch. Histol. Jpn

View full text Add to dashboard Cite

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“…They are proposed to function as a mechanical link and as a permeability barrier separating the extracellular space outside the myelin sheath from the intramyelinic space between the lamellae (Hall and Williams 1969;Revel and Hamilton 1969;Mugnaini and Schnapp 1974;Tabira et al 1978;MacKenzie et al 1984). The autotypic tight junctions present in different components of noncompact myelin contain distinct junctional complexes including the paranodal loops, Schmidt-Lanterman incisures, and mesaxons (Poliak et al 2002).…”

mentioning

confidence: 99%

Tricellulin Is Expressed in Autotypic Tight Junctions of Peripheral Myelinating Schwann Cells

Kikuchi

Ninomiya

Tatsumi

et al. 2010

J Histochem Cytochem.

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Autotypic tight junctions are formed by tight junction-like structures in three regions of myelinating Schwann cells, the paranodal loops, Schmidt–Lanterman incisures, and outer/inner mesaxons, and various tight junction molecules, including claudin-19 and junctional adhesion molecule (JAM)-C. Our findings demonstrate the identification and subcellular distribution of a novel tricellular tight junction protein, tricellulin (TRIC), in the autotypic tight junctions of mouse myelinating Schwann cells, compared with the autotypic adherens junction protein E-cadherin and the autotypic tight junction protein JAM-C, which are expressed in the paranodal loops, Schmidt–Lanterman incisures, and mesaxons. In realtime RT-PCR, the expression level of TRIC mRNA was about 10-fold higher in the sciatic nerve than in the spinal cord or cerebrum. In immunostaining, TRIC signals were completely restricted to the peripheral nervous system (PNS) and strongly concentrated at the paranodal loops, Schmidt–Lanterman incisures, and mesaxons of myelinating Schwann cells. In addition, TRIC was expressed in the thin region of the paranode and there was a gap between TRIC and the Na+ channel. Furthermore, TRIC was more distally located from the node than E-cadherin and was colocalized with JAM-C. It is possible that TRIC may be a component to maintain the integrity for PNS myelin function and morphology. This manuscript contains online supplemental material at http://www.jhc.org . Please visit this article online to view these materials. (J Histochem Cytochem 58:1067–1073, 2010)

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Subtle myelin defects in PLP‐null mice

Rosenbluth

Nave

Mierzwa

et al. 2006

Glia

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This study explores subtle defects in the myelin of proteolipid protein (PLP)-null mice that could potentially underlie the functional losses and axon damage known to occur in this mutant and in myelin diseases including multiple sclerosis. We have compared PLP-null central nervous system WNS) myelin with normal myelin using ultrastructural methods designed to emphasize fine differences. In the PLP-null CNS, axons large enough to be myelinated often lack myelin entirely or are surrounded by abnormally thin sheaths. Short stretches of cytoplasm persist in many myelin lamellae. Most strikingly, compaction is incomplete in this mutant as shown by the widespread presence of patent interlamellar spaces of variable width that can be labeled with ferricyanide, acting as an aqueous extracellular tracer. In thinly myelinated fibers, interlamellar spaces are filled across the full width of the sheaths. In thick myelin sheaths, they appear filled irregularly but diffusely. These patent spaces constitute a spiral pathway through which ions and other extracellular agents may penetrate gradually, possibly contributing to the axon damage known to occur in this mutant, especially in thinly myelinated fibers, where the spiral path length is shortest and most consistently labeled. We show also that the "radial component" of myelin is distorted in the mutant ("diagonal component") extending across the sheaths at 45 degrees instead of 90 degrees. These observations indicate a direct or indirect role for PLP in maintaining myelin compaction along the external surfaces of the lamellae and to a limited extent, along the cytoplasmic surfaces as well and also in maintaining the normal alignment of the radial component. (c) 2006 Wiley-Liss, Inc

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An experimental analysis of interlamellar tight junctions in amphibian and mammalian C.N.S. myelin

Cited by 61 publications

References 27 publications

Ultrastructure of the radial components of the mouse optic nerve and its changes during wallerian degeneration.

Ultrastructure of the radial components of the mouse optic nerve and its changes during wallerian degeneration.

Tricellulin Is Expressed in Autotypic Tight Junctions of Peripheral Myelinating Schwann Cells

Subtle myelin defects in PLP‐null mice

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