An Experimental and Computational Study on the Rate Constant of Electrochemically Generated N-Acetyl-p-Quinoneimine with Dimethylamine

Shafiei, Hadi; Haqgu, M.; Nematollahi, Davood; Gholami, Mohammad Reza

doi:10.1016/s1452-3981(23)15506-4

“…These selected analytes include both endogenous (e.g., dopamine) and exogenous (e.g., doxorubicin) targets. In addition to these molecules, many other neurotransmitters (e.g., norepinephrine 14 ), hormones (e.g., melatonin 15 ), lipids (e.g., cholesterol 16 ), and drugs (e.g., acetaminophen 17 ) have been reported with seemingly compatible oxidation potentials. MT sensors were prepared on cleanroom-fabricated gold microelectrodes containing additional electrodeposited gold nanostructures (Figure S1).…”

mentioning

confidence: 99%

Self-Assembled Monolayer Transporters Enable Reagentless Analysis of Small Molecule Analytes

Flynn,

Riordan,

Young

et al. 2024

Preprint

0

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The detection of small molecules beyond glucose remains an ongoing challenge in the field of biomolecular sensing owing to their small size, diverse structures, and lack of alternative non-enzymatic sensing methods. Here, we present a new reagentless electrochemical approach for small molecule detection that involves directed movement of electroactive analytes through a self-assembled monolayer to an electrode surface. Using this method, we demonstrate detection of several physiologically relevant small molecules as well as the capacity for the system to operate in several biological fluids. We anticipate that this mechanism will further improve our capacity for small molecule measurement and provide a new generalizable monolayer-based technique for electrochemical assessment of various electroactive analytes.

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“…These selected analytes include both endogenous (e.g., dopamine) and exogenous (e.g., doxorubicin) targets. In addition to these molecules, many other neurotransmitters (e.g., norepinephrine), hormones (e.g., melatonin), lipids (e.g., cholesterol), and drugs (e.g., acetaminophen) have been reported with seemingly compatible oxidation potentials.…”

mentioning

confidence: 99%

Self-Assembled Monolayer Transporters Enable Reagentless Analysis of Small Molecule Analytes

Flynn,

Riordan,

Young

et al. 2024

ACS Sens.

1

0

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The detection of small molecules beyond glucose remains an ongoing challenge in the field of biomolecular sensing owing to their small size, diverse structures, and lack of alternative non-enzymatic sensing methods. Here, we present a new reagentless electrochemical approach for small molecule detection that involves directed movement of electroactive analytes through a self-assembled monolayer to an electrode surface. Using this method, we demonstrate detection of several physiologically relevant small molecules as well as the capacity for the system to operate in several biological fluids. We anticipate that this mechanism will further improve our capacity for small molecule measurement and provide a new generalizable monolayer-based technique for electrochemical assessment of various electroactive analytes.

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Electrochemical Derivatization of Acetaminophen for Indirect Determination of Eflornithine Using β‐CD Modified Glassy Carbon Electrode

Barnaji

¹

,

Salehzadeh

²

,

Darbasizadeh

³

et al. 2019

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In the present work, the oxidation of acetaminophen in the absence and presence of eflornithine was electrochemically investigated by means of cyclic voltammetry at a glassy carbon electrode (GCE). Our results indicate that N‐acetyl‐p‐benzoquinone imine (NAPQI) produced from two‐electron electrochemical oxidation of acetaminophen participates in a Michael addition reaction with eflornithine via an ECE mechanism. This fact was used for the determination of eflornithine using differential pulse voltammetry (DPV) technique on the surface of β‐Cyclodextrin modified glassy carbon (β‐CD/GC) electrode. β‐CD/GC electrode was prepared through an electrodeposition procedure and characterized by Fourier‐transform infrared spectroscopy (FT‐IR), Cyclic Voltammetry (CV), Field Emission Scanning Electron Microscopy (FESEM) and Energy‐dispersive X‐ray spectroscopy (EDS) techniques. Under optimum conditions, the β‐CD/GC electrode showed a good linearity as a function of the eflornithine concentration over the range from 5 to 100 μM with detection limit and quantification limit of 1.94 and 5.8 μM, respectively. Finally, the proposed protocol was confirmed to be successful in determination of eflornithine in human urine samples with good recovery, ranging from 97.2 % to 104.8 %.

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An Experimental and Computational Study on the Rate Constant of Electrochemically Generated N-Acetyl-p-Quinoneimine with Dimethylamine

Cited by 17 publications

References 32 publications

Self-Assembled Monolayer Transporters Enable Reagentless Analysis of Small Molecule Analytes

Self-Assembled Monolayer Transporters Enable Reagentless Analysis of Small Molecule Analytes

Self-Assembled Monolayer Transporters Enable Reagentless Analysis of Small Molecule Analytes

Electrochemical Derivatization of Acetaminophen for Indirect Determination of Eflornithine Using β‐CD Modified Glassy Carbon Electrode

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