2021
DOI: 10.1039/d1an01801a
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An experimental and numerical modelling investigation of the optical properties of Intralipid using deep Raman spectroscopy

Abstract: Monte Carlo modelling of Raman spectroscopy in tissue phantoms to validate code and provide insight into the optical properties of Intralipid.

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Cited by 4 publications
(6 citation statements)
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“…The main components of INT consist of the soybean oil, lecithin, glycerin, and water, in which the soybean oil and lecithin with high optical scattering properties exhibit the potential to serve as the OCT contrast agent. 22,23 However, INT is able to be rapidly cleared from the blood circulation system in 3a and c). Interestingly, when the OCT signal intensity reached the peak, they began to decrease, demonstrating that both INT and P-INT had excellent biocompatibility and were able to be easily metabolized from the body in vivo.…”
Section: Introductionmentioning
confidence: 99%
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“…The main components of INT consist of the soybean oil, lecithin, glycerin, and water, in which the soybean oil and lecithin with high optical scattering properties exhibit the potential to serve as the OCT contrast agent. 22,23 However, INT is able to be rapidly cleared from the blood circulation system in 3a and c). Interestingly, when the OCT signal intensity reached the peak, they began to decrease, demonstrating that both INT and P-INT had excellent biocompatibility and were able to be easily metabolized from the body in vivo.…”
Section: Introductionmentioning
confidence: 99%
“…In addition, INT solution is usually used to produce optical tissue phantoms in vitro , whose scattering coefficients can be accessed according to the signal intensity measured by NIR spectroscopy. The main components of INT consist of the soybean oil, lecithin, glycerin, and water, in which the soybean oil and lecithin with high optical scattering properties exhibit the potential to serve as the OCT contrast agent. , However, INT is able to be rapidly cleared from the blood circulation system in vivo , significantly limiting its efficacy as an OCT theranostics agent.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…The application of a spatial offset on the surface of the obscuring barrier during measurements allows for the collection of Raman photons that have been scattered by subsurface analytes, and the delineation of compositional changes at depth is possible when comparing spectra collected at offsets of different magnitudes . There are various approaches that allow excitation of multilayered samples, such as mammalian tissue analogues containing buried SERS-active nanoparticles (NPs), and the offset collection of subsurface-scattered Raman photons, as highlighted in a recent review article by Nicolson et al These techniques span numerous different optical geometries including point-based collection SORS, where the point of collection is offset from the point of excitation by a linear offset vector; ring-collection SORS, where the Raman photons are collected in a circular array around a central excitation point and the spatial offset magnitude is calculated as the radius of the collection ring; and transmission Raman spectroscopy, where the excitation and collection points are situated on the opposite sides of a sample …”
Section: Introductionmentioning
confidence: 99%
“…15 There are various approaches that allow excitation of multilayered samples, such as mammalian tissue analogues containing buried SERSactive nanoparticles (NPs), and the offset collection of subsurface-scattered Raman photons, as highlighted in a recent review article by Nicolson et al 16 These techniques span numerous different optical geometries including point-based collection SORS, where the point of collection is offset from the point of excitation by a linear offset vector; ring-collection SORS, where the Raman photons are collected in a circular array around a central excitation point and the spatial offset magnitude is calculated as the radius of the collection ring; and transmission Raman spectroscopy, where the excitation and collection points are situated on the opposite sides of a sample. 17 In recent years, SESORS has been explored as an imaging technique for the detection of various disease states through biological tissues via the interaction of biomolecular targets with biofunctionalized SERS-active NPs that produce highly specific molecular fingerprint spectra. Imaging is traditionally undertaken by tracking the intensity of a particular SERS band, pertaining to the targeted NPs of interest, across a grid on the surface of a biological sample to ascertain the location of the NPs at depth in the two-dimensional (2D) imaging plane.…”
Section: ■ Introductionmentioning
confidence: 99%