In recent years, researchers have shown great interest in intelligent electrochemical interfaces due to their potential applications. This work addresses the challenge of integrating multiple stimuli‐responsive properties while maintaining a robust electrochemical response. In this work, graphdiyne (GDY) is loaded on glassy carbon electrode (GCE) by dropping method to obtain the GDY/GCE layer. Copper hexacyanoferrate (CuHCF) is then electrodeposited onto the GDY/GCE, creating a catalytic layer for N‐acetylcysteine (NAC). The stimuli‐responsive hydrogel poly(N,N‐diethylacrylamide) (PDEA) is applied on the catalytic layer surface via drop‐coating. This configuration facilitated reversible electrochemical responses to changes in temperature, electrolyte composition, and pH levels. By analyzing peak current differences and corresponding potential changes, a type of logic gate is successfully simulated, including a 4‐input/7‐output logic gate and a three‐state logic gate. This novel approach significantly advanced the construction of electrochemical pharmaceutical logic gates.