An experimental and theoretical approach on the kinetics and mechanism for the formation of a four-membered (S, S) chelated Pt(ii) complex

Abstract

A biomolecular substitution reaction on a Pt(ii) complex by a dithiocarbamate derivative has been studied experimentally and theoretically, and the resultant product complex is a four-membered (S, S) chelate possessing cytotoxic properties.

Losartan delays the progression of streptozotocin‐induced diabetic cataracts in albino rats

“…[3,4] Chronic hyperglycemia alters the lenticular integrity that further leads to cataract formation. [5] Although hyperglycemia, polyol pathway, oxidative stress, and advanced glycation end products are key factors for the formation of diabetic cataracts, [6][7][8][9][10] many other pathways need to be explored.…”

“…[3,4] Chronic hyperglycemia alters the lenticular integrity that further leads to cataract formation. [5] Although hyperglycemia, polyol pathway, oxidative stress, and advanced glycation end products are key factors for the formation of diabetic cataracts, [6][7][8][9][10] many other pathways need to be explored.A plethora of studies have demonstrated that the ocular reninangiotensin system (RAS) may also be involved in ocular pathophysiology and receptors such as AT1 receptor have been identified in various tissues of the eyes. [11][12][13][14][15][16] Moreover, diabetes activates the ocular RAS in the eye [14] and angiotensin II which is an important mediator of RAS exacerbates the angiogenic and the inflammatory action in the eye and leading to several ocular disorders such as uveitis, macular degeneration, diabetic retinopathy, and glaucoma, [17][18][19][20] whereas, RAS modulators such as angiotensin receptor blockers and angiotensin-converting enzyme inhibitors reduce the risk of such eye diseases like diabetic retinopathy [21][22][23] and glaucoma.…”

A Convenient Synthesis of 1,2‐Disubstituted‐cis‐3,4‐Dihydroxypyrrolidines via an Ugi‐Four‐Component‐Reaction/Cycloisomerization/Dihydroxylation Protocol

“…[14] Interestingly, the strategic position of the double bond in this heterocycle offers a unique opportunity as a platform for the synthesis of relevant molecules (iminosugars) through processes such as stereoselective dihydroxylation reactions. [5,[15][16][17] However, although several different synthetic approaches to the 3-pyrroline core have been reported to date, including metal-mediated reactions (Ru, [18][19][20][21] Pd, [22,23] Au, [24] Cu, [25][26][27] Ag, [28][29][30] Cr [31] ), cycloaddition reactions, [32][33][34][35] carbene-insertion reactions, [36] dehydration reactions, [37] organocatalytic processes, [38] and other miscellaneous reactions, [39][40][41] no MCRs, and specifically Ugi four-component-reactions, have been reported.…”