An experimental and theoretical vibrational spectra of isoniazide

Vibrational spectroscopy of 4-hydroxybenzhydrazide and its O,N-deuterated isotopologue accompanied by X-ray structure refinement

“…This assignment is different from what has been made for similar compoundisoniazide [23]. In the present work, the computed 1352 cm À1 mode is related to internal coordinate defined by opposite change of the NNH angles, for example b(N1-N2-H21) À b(N1-N2-H22).…”

“…4). Since these bands are sensitive to deuteration and were observed for other benzhydrazides without hydroxyl group [12,23], they must result from the NH 2 and NH group vibrations. According to the literature data [12] and performed calculations, the lowest frequency band at 3196 cm À1 is definitely due to the n s (NH 2 ) vibration.…”

Compatibility Study Between Isoniazid and Pharmaceutical Excipients Used in Solid Dosage Forms

“…The spectral data observed in the FTIR spectra were consistent with other authors. 5,6 Compatibility studies between isoniazid and excipients…”

“…4 The action mechanism of INH is not totally understood however, the pharmacological activity of the biologically active molecule is related to its chemical structure. 5,6 Several authors have reported on the stability of isoniazid [7][8][9][10] and its compatibility with drugs [11][12][13] and pharmaceutical excipients. 14 Given the above, the development of dosage forms containing isoniazid should be judicious.…”

Crystal structures of cocrystals of 2,7-dihydroxynaphthalene with isoniazid and piracetam

“…The IR spectra of solid DHN, PIR, INH, DHN-INH and DHN-PIR polycrystalline powders, and of single crystals of the DHN-INH and DHN-PIR cocrystals were acquired using a Bruker Tensor 27 spectrophotometer equipped with an attenuated total reflectance (ATR) accessory (16 scans, spectral range 600-4000 cm À1 , resolution 4 cm À1 ). The IR spectra of DHN, INH and PIR were assigned as reported previously (Yilmaz et al, 2008;Uma Maheswari et al, 2014;Nguyen et al, 2019).…”