An Experimental Assessment of the Therapeutic Efficacy of Amino Compounds

Chemotherapy in Streptococcal Infections

“…weight is about 150 mgm. (Whitby, 1937). This is several times the full effective dosage; our investigations (De and Basu, 1937) tend to show that 7.5 mgm.…”

Sulfapyridine, Sulfanilamide, and Specific Antiserum in Experimental Type Iii Pneumococcic Infections

“…Similarly, a value of 5 would be obtained if all mice died at the end of the fifth day or if 2 died at the end of each of the fourth, fifth, and sixth days, leaving in the last 2 instances no survivors. The 7-day period of observation, considered adequate by Whitby (1,16,17,18) was found to be insufficient by others who observed a significant number of deaths between the second and fourth weeks of observation (3, 4, 9, 10, 12, 19, 20, 21). …”

Chemotherapy of Streptococcal Infections

“…(Whitby, 1937). This is several times the full effective dosage; our investigations (De and Basu, 1937) [Jan., 1938 formation of methemoglobinemia, when inhalation of oxygen would help in its disappearance within a day (Paton and Eaton, 1937 (Kolm, 1937), toxic optic neuritis' (Bucy, 1937) Fuge (1935) treated 120 patients suffering from puerperal fever with large doses of prontosil-red and only three died.…”