Indoor distance measurement technology utilizing Zigbee’s Received Signal Strength Indication (RSSI) offers cost-effective and energy-efficient advantages, making it widely adopted for indoor distance measurement applications. However, challenges such as multipath effects, signal attenuation, and signal blockage often degrade the accuracy of distance measurements. Addressing these issues, this study proposes a combined filtering approach integrating Kalman filtering, Dixon’s Q-test, Gaussian filtering, and mean filtering. Initially, the method evaluates Zigbee’s transmission power, channel, and other parameters, analyzing their impact on RSSI values. Subsequently, it fits a signal propagation loss model based on actual measured data to understand the filtering algorithm’s effect on distance measurement error. Experimental results demonstrate that the proposed method effectively improves the conversion relationship between RSSI and distance. The average distance measurement error, approximately 0.46 m, substantially outperforms errors derived from raw RSSI data. Consequently, this method offers enhanced distance measurement accuracy, making it particularly suitable for indoor positioning applications.