An experimental demonstration of a new type of proton computed tomography using a novel silicon tracking detector

Taylor, Jon; Poludniowski, Gavin; Price, Tony; Waltham, Chris; Allport, Philip Patrick; Casse, G.; Esposito, Michela; Evans, Philip; Green, S.; Manger, Sam; Manolopoulos, S.; Nieto-Camero, Jaime; Parker, David J.; Symons, J.E.; Allinson, Nigel M.

doi:10.1118/1.4965809

Cited by 21 publications

(21 citation statements)

References 30 publications

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“…Hansen et al 2016). Many groups are known to be designing, building or operating pCT (or heavier ion CT) prototypes (Rinaldi et al 2013, Taylor et al 2016, Meyer et al 2017, Tanaka et al 2018 and initial reports of RSP accuracy support these endeavours (Giacometti et al 2017).…”

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confidence: 99%

Two-dimensional noise reconstruction in proton computed tomography using distance-driven filtered back-projection of simulated projections

et al. 2018

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Relative proton stopping power (RSP), the ratio of the proton stopping power of a given material to that of water at a given energy, is necessary for most clinical dose calculation methods used in proton therapy. RSP is currently estimated by x-ray computed tomography (CT) scans in clinical practice (Taasti et al 2018). The conversion from photon attenuation coefficients to RSP contributes considerably to range uncertainties (Paganetti 2012, Yang et al 2012). The potential of reducing these uncertainties by direct RSP measurements at the treatment position has motivated the recent revival of proton computed tomography (pCT), which was first proposed by Cormack in the early 1960s (Cormack 1963). Modern pre-clinical pCT scanners measure the positions and residual energies of the protons behind (and in some designs also in front of) the patient in a series of projections, from which an RSP image can be reconstructed (

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confidence: 99%

Two-dimensional noise reconstruction in proton computed tomography using distance-driven filtered back-projection of simulated projections

et al. 2018

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“…low mass detectors) to prevent multiple Coulomb scattering from deteriorating resolution performance. Such performance has been demonstrated for the PRaVDA SSDs [24] .…”

Section: Requirements and Design Specificationsmentioning

confidence: 72%

PRaVDA: The first solid-state system for proton computed tomography

et al. 2018

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“…This modality would definitely improve with a clinical use of proton radiography, which provides direct information on the density of the tissues, enhancing the precision of treatment planning. In this framework, different proton radiography systems have been tested [1][2][3]. Our group investigated the possibility of using emulsion detectors [4] to image different phantoms of the proton therapeutic beam at the Paul Scherrer Institut (PSI) in Villigen, Switzerland.…”

Section: Introductionmentioning

confidence: 99%

Proton Radiography by Multiple Coulomb Scattering with Nuclear Emulsion Detectors

et al. 2019

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The possibility of performing proton radiography by using the proton angular spread due to Coulomb multiple scattering was investigated, for the first time, with an emulsion film detector. Two different phantoms were irradiated with the therapeutic proton beam at the Paul Scherrer Institut (PSI) in Villigen, Switzerland. The first one is a simple polymethylmethacrylate (PMMA) block having two different thicknesses (4 cm and 3 cm), and the second one is a PMMA cube with five aluminum rods embedded along a diagonal. Only one emulsion film was needed to perform the radiography, an important issue as the analysis of this kind of detector is time-consuming. Furthermore, the method showed an enhanced contrast when high atomic-number materials are traversed. This gives an advantage, when compared to proton range radiography.

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An experimental demonstration of a new type of proton computed tomography using a novel silicon tracking detector

Cited by 21 publications

References 30 publications

Two-dimensional noise reconstruction in proton computed tomography using distance-driven filtered back-projection of simulated projections

Two-dimensional noise reconstruction in proton computed tomography using distance-driven filtered back-projection of simulated projections

PRaVDA: The first solid-state system for proton computed tomography

Proton Radiography by Multiple Coulomb Scattering with Nuclear Emulsion Detectors

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