Network densification is a key technology to achieve the spectral efficiency (SE) expected in 5G wireless networks and beyond. However, the proximity between transmitters and receivers increases the interference levels, becoming a major drawback. To overcome this problem, several interference management techniques have been proposed to increase the signalto-interference-plus-noise ratio (SINR). Interference alignment (IA) algorithms have been extensively studied due to their capability to achieve optimal degrees of freedom (DoFs) in interference channels (ICs). Nevertheless, most of the works are limited to a purely theoretical analysis based on non-realistic assumptions such as perfect channel state information (CSI) and the synchronization of all nodes in the network. To the best of our knowledge, only a few articles address the IA implementation using reconfigurable hardware. To cover this lack, this paper proposes a practical design of the IA algorithm based on the SINR maximization, known as MAX-SINR, considering a multiuser IC. Each transmitter and receiver is implemented on the National Instruments USRP-2942. A practical solution for the channel estimation and synchronization stages in an IC, that are usually omitted in theoretical works, is developed. The performance of the proposed implementation is shown in terms of the SINR gain, SE, and bit error rate (BER). Unlike previous works, all the results are based on real measurements providing valuable insights into the performance of IA algorithms.Index Terms-Interference alignment (IA), multi-user interference channels (ICs), universal software radio peripheral (USRP).