An Experimental Evaluation of the Thermodilution Method for Determination of Cardiac Output and of Intracardiac Right-to-Left Shunts

Hedvall, Gunnel; Kjellmer, Ingemar; Olsson, Torsten

doi:10.3109/00365517309082419

Cited by 16 publications

(9 citation statements)

References 8 publications

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“…To obtain the build-up time (BC) for the primary curve, the time between injection and peak concentration (AB) is measured and BC = fx AB, where the factor for the relation between build-up time and injection to peak concentration time (f) is calculated from data without shunting. Reproduced with permission from Hedvall Get aL 59 provides the closest representation of true values and does not need oxygen-enriched inspiratory air as in the blood gas method. 59 In this method the proportion of injectate passing through the shunt is obtained by the ratio of the shunt triangle (left) to the sum of both triangles.…”

Section: Lntra-and Extra-cardiac Shuntsmentioning

confidence: 99%

“…59 In this method the proportion of injectate passing through the shunt is obtained by the ratio of the shunt triangle (left) to the sum of both triangles. 59,134 In addition, the absolute blood flow through the shunt may be calculated by using the fraction of shunt and the total left ventricular output, if the latter can be estimated from a thermodilution curve after injection in the left atrium. 59…”

Section: Lntra-and Extra-cardiac Shuntsmentioning

confidence: 99%

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Errors in the measurement of cardiac output by thermodilution

1993

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Section: Lntra-and Extra-cardiac Shuntsmentioning

confidence: 99%

Section: Lntra-and Extra-cardiac Shuntsmentioning

confidence: 99%

Errors in the measurement of cardiac output by thermodilution

1993

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“…The values were error of the mean (SEM) were calculated. Com-obtained after the animals had been breathing parisons were carried out with the help of Group either 30 per cent or [10][11][12][13][14][15] None of the animals showed any change of blood pressure during the injection of microspheres. Some of the rabbits had a slight depression of heart frequency, but it was restored in a few seconds.…”

Section: The Microspheresmentioning

confidence: 99%

The influence of hypoxia on uterine and maternal placental blood flow, and the effect of α-adrenergic blockade

Karlsson¹

1974

Journal of Perinatal Medicine

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The peripheral blood flow in all species is widely to the placenta was reduced from about 60 to redistributed during hypoxia. Dependent upon about 32 per cent during hypoxia. the species and the respiratoryresponsealowering In a study using the macroaggregate distribution of the arterial P Oa gives an increase in c rdiac technique POWER et al. [ISjfoundthatthedistribuoutput and in heart f requency, or a decrease in the tion in the placenta became more uniform, when same parameters [11]. The general pattern of the animal was hypoxic, giving a less variable response is a reduction of blood flow to most local relation between the maternal and fetal flow. organs, but preservation or even an increase of This indicates a placental vasodilatation. blood flow to vital organs -the brain and the The present experiments were performed to myocardium. In pregnancy a special Situation is investigate whether hypoxic vasoconstriction established since the placenta is a non-vital organ takes place in the uterus-placental circulation in for the mother but a vital organ for the fetus. the pregnant rabbit, and if so, what the mechanism The question arises, whether the Uterus-for vasoconstriction might be. placenta circuit will take part in the general peripheral vasoconstriction during maternal . _,, . . Έ ^, , ϊ . * i^ t ui j Λ ·ιι t-* Material and Methods hypoxia, or whether the blood flow will be preserved.The material consisted of 14 pregnant rabbits Great difficulties have earlier been encountered with dated gestations from 25 to 30 days. The when studying the uterine circulation. The posi-pregnant term for rabbits is 31 ± 2 days. The tion of the organ, with several vessels both on the mean body weight was 4.39 kg i 0.16 (SD). inflow and outflow side, has complicated the study Anesthesia was induced with pentothal (25 mg/ of circulation of this special organ. Information on kg) through a catheter in a lateral ear-vein, and the uterine circulation in pregnancy during hypo-maintained with additional small amounts of xia is conflicting. Thus ASSALI et al.[2] found a pentothal. The rabbit was placed on a warm table progressive increase in blood flow to the Uterus and the trachea cannulated. The animal was in pregnant ewes, when these were breathing artificially ventilated with known gas mixtures 10 per cent oxygen, while DUNCAN et al.[5] using a small animal Ideal Pump (volume/ found a reduction in the total uterine blood flow, f requency = 22 ml/36 rpm). probably because of local vasoconstriction during Arterial blood pressure and heart frequency were hypoxia. The latter authors performed their in-registered through a catheter in the right brachial vestigations on rabbits with the microsphere artery. The Signals were monitored by a STATHAM technique and found, apart from the reduction P 23 AC transducer, atnplified and recorded on a of uterine blood flow, a redistribution of the total GRASS model 7 polygraph. Samples for blood flow within the organ, so that the fraction going gas determinations were taken through the same

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“…Indeed, we can expect that the TPTD curve could be a useful monitoring tool to guide intra-cardiac shunt correction as a significant relationship was demonstrated between TPTD curve and blood gas methods to measure shunt fractions [3,7]. The present finding reminds us that despite gaining an increasely detailed understanding during the last sixty years, indicator dilution curves monitoring knowledge could be described as an ''endless frontier''.…”

Section: Karim Bendjelid MD Phdmentioning

confidence: 52%

Monitoring intra-cardiac shunts correction with transpulmonary thermodilution curve: the best is yet to come!

Bendjelid

2011

J Clin Monit Comput

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An Experimental Evaluation of the Thermodilution Method for Determination of Cardiac Output and of Intracardiac Right-to-Left Shunts

Cited by 16 publications

References 8 publications

Errors in the measurement of cardiac output by thermodilution

Errors in the measurement of cardiac output by thermodilution

The influence of hypoxia on uterine and maternal placental blood flow, and the effect of α-adrenergic blockade

Monitoring intra-cardiac shunts correction with transpulmonary thermodilution curve: the best is yet to come!

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