An Experimental Models (In-Vivo and In-Vitro) Used for the Study of Antidiabetic agents

Dash, Sribatsa Lanchhana; Gupta, Pranav; Dubey, Anubhav; Sahu, Vikram Kumar; Amit Mishra,

doi:10.17762/jaz.v44i4.1461

Cited by 3 publications

(2 citation statements)

References 40 publications

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“…The results underwent evaluation through a Two-Way Analysis of Variance. The statistical distinctions between groups were examined using Duncan's Multiple Range Test at a 5% level of significance (Dash et al, 2023)…”

Section: Discussionmentioning

confidence: 99%

Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa

Naz,

Kashif,

Tawab

et al. 2023

ANST

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This study used the hydrodistillation method to extract essential oil from Cannabis sativa (C.sativa) leaves, while its chemical composition was examined through gas chromatography-mass spectrometry. Experiments were conducted on alloxan-induced hyperglycemic rabbits (albino), with metformin as the reference medication for comparative analysis to evaluate its potential in managing diabetes. Chemical analysis showed that the principal components of C.sativa essential oil were caryophyllene (46.63%), d-limonene (7.123%) and cis-β-farnescene (9.115%), humulene (13.153%) and trans-αbergamotene (6.592%). The minor components (˂5%) include α-pinene (3.720%), β-myrcene (1.910%), cineole (2.340%), valencene (1.614%), β-bisabolene (1.897%) and unidentified components (4.201-4.452%) were respectively. Intraperitoneal administration of C. sativa oil (0.7, 0.9 and 1.2µl/kg b.wt.) to hyperglycemia for 14 days resulted in a noteworthy decrease in both hepatic and fasting blood glucose levels. Meanwhile, there was a marked increase in the hepatic concentration of glycogen. The oil administration exhibited a reduced yet favourable anti-hyperglycemic potential compared to the reference antidiabetic drug. The study's findings indicate that the essential oil derived from C. sativa leaves cultivated in Pakistan is characterized as a Beta Caryophyllene chemotype. Remarkably, the oil demonstrated significant efficacy in lowering glucose levels and showed promise in mitigating hyperglycemia-induced dyslipidemic complications in rabbits induced with alloxan.

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Section: Discussionmentioning

confidence: 99%

Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa

Naz,

Kashif,

Tawab

et al. 2023

ANST

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“…These are matters that your doctor and nutritionist would recommend to you. In order to normalise blood glucose levels, it is helpful to be consistent with the meal types, nutritional information, and timing of consumption on a daily basis [21][22][23][24][25].…”

Section: Diet and Nutritional Planmentioning

confidence: 99%

Homeopathic Medicinal Products and Importance in Diabetes

Dubey,

Kumari,

Pandey

2024

IJHNM

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Background: Diabetes is a condition that happens when your blood sugar (glucose) is too high. It develops when your pancreas doesn’t make enough insulin or any at all, or when your body isn’t responding to the effects of insulin properly. Diabetes affects people of all ages. Most forms of diabetes are chronic (lifelong), and all forms are manageable with medications and/or lifestyle changes. So many health problems can develop in diabetic people, like heart diseases, kidney diseases, eye problems, etc. Diabetes mellitus is a chronic disease. A qualified homeopathic doctor needs to be consulted for the selection of the right medicine and its potency. Objective: There are many allopathic medicines available for the treatment of diabetes, but they have lots of side effects. The main objective of this study is to find out the appropriate homeopathic medicines for the treatment of diabetes. Methods: A literature search was conducted on the databases, namely Science Direct and PubMed, with the help of different keywords such as "homeopathic medicine treatment of diabetes." The search was customized by applying the appropriate filters so as to get the most relevant articles to meet the objective of this review article. Result: There are different research and review papers based on the homeopathic medicine treatment of diabetes and the activity of new drug molecules. Conclusion: On the basis of our study, we found that some treatments approach homeopathic medicines for the treatment of diabetes and suggested that if we used homeopathic medicine to reduce the side effects of allopathic medicines.

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Formulation Approaches for Deep Eutectic Solvents Solubilized APIs

Rajeshwari

2024

J. Res. Appl. Sci. Biotechnol.

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Increasing the efficacy of currently available medications is one of the pharmaceutical industry's main objectives. It is far simpler to develop current medications or enhance their efficacy than to create novel therapeutic candidates. This can be accomplished by altering deep eutectic solvents are prepared for solubility in the formulation techniques improvements made to different Active Pharmaceutical Ingredients (APIs). Usually, to modify DES, compounds having hazardous profiles that were previously well-known determined. DESs are thought to function as solubilization carriers. The evolution Organic solvents such as ethanol and acetone ethers are typically needed for soluble medicines. The melting of APIs is improved as a result. Along with improving the solubility of currently available medications, DESs also has a number of other uses.

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An Experimental Models (In-Vivo and In-Vitro) Used for the Study of Antidiabetic agents

Cited by 3 publications

References 40 publications

Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa

Assessment of the Antidiabetic Properties of Essential Oil from Cannabis sativa

Homeopathic Medicinal Products and Importance in Diabetes

Formulation Approaches for Deep Eutectic Solvents Solubilized APIs

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