Long-term stability of emplacement drifts and potential near-field fluid flow resulting from coupled effects are among the concerns for safe disposal of high-level nuclear waste (HLW). A number of factors can induce drift instability or change the near-field flow patterns. Repetitive seismic loads from earthquakes and thermal loads generated by the decay of emplaced waste are two significant factors. One of two key technical uncertainties (KTU) that can potentially pose a high risk of noncompliance with the performance objectives of 10 CFR Part 60 is the prediction of thermal-mechanical (including repetitive seismic load) effects on stability of emplacement drifts and the engineered barrier system. The second KTU of concern is the prediction of thermal-mechanical-hydrological (including repetitive seismic load) effects on the host rock surrounding the engineered barrier system. The Rock Mechanics research project being conducted at the Center for Nuclear Waste Regulatory Analyses (CNWRA) is intended to address certain specific technical issues associated with these two KTUs. This research project has two major components: (i) seismic response of rock joints and a jointed rock mass and (ii) coupled thermal-mechanical-hydrological (TMH) response of a jointed rock mass surrounding the engineered barrier system (EBS). This final report summarizes the research activities concerned with the repetitive seismic load aspect of both these KTUs. A literature review was conducted at the beginning of this research project to establish the state of knowledge available in the open literature relevant to performance of underground excavations and associated phenomena when subjected to seismic waves. Critical assessment of the information identified several technical deficiencies or lack of information, particularly with regard to analysis and prediction of dynamic response of underground structures excavated in fractured rock masses. Furthermore, the knowledge gained in this literature search was used to formulate the laboratory and field experiments conducted in this research project. Laboratory experiments on natural joints of Apache Leap tuff using cyclic pseudostatic and dynamic loads indicate that the mobilized shear strength in the reverse direction of shearing (that is, moving toward the original starting point of shearing) is always less than that in the forward direction. This phenomenon has a significant consequence on the stability of underground openings. It was also observed that the dilation is nearly recovered in reverse shearing. These observations are consistent with some recent studies by others. The commonly used rock joint constitutive models, namely, Coulomb-Slip, Barton-Bandis, and Continuously-Yielding, were developed primarily for uniaxial shearing. Their extension to model joint reverse behavior is questionable. Although in later publications a procedure was given to use the original equations of Barton-Bandis model in reverse direction, the modified procedure to Barton-Bandis model does not consider the...