An experimental study of sorption/desorption of selected radionuclides on carbon nanomaterials: a quest for possible applications in future nuclear medicine

Kazakov, Andrey G.; Garashchenko, B. L.; Yakovlev, R. Yu.; Винокуров, С. Е.; Kalmykov, Stepan N.; Myasoedov, Β. F.

doi:10.1016/j.diamond.2020.107752

Cited by 23 publications

(16 citation statements)

References 54 publications

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“…Kukleva et al, in 2006, studied the uptake of 223 Ra in the superparamagnetic nanoparticles (SPION) of Fe 3 O 4 (diameters between 4 and 26 nm). The in vitro results showed yields greater than 85% in PBS, and the stability tests in PBS, bovine plasma, and serum showed a cumulative release of 223 Ra below 5% [ 101 ]. Westrøm et al, in 2018, proposed calcium carbonate microparticles as carriers of 224 Ra.…”

Section: Nanoradiopharmaceuticals Based On Alpha Emittersmentioning

confidence: 99%

Nanoradiopharmaceuticals Based on Alpha Emitters: Recent Developments for Medical Applications

et al. 2021

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The application of nanotechnology in nuclear medicine offers attractive therapeutic opportunities for the treatment of various diseases, including cancer. Indeed, nanoparticles-conjugated targeted alpha-particle therapy (TAT) would be ideal for localized cell killing due to high linear energy transfer and short ranges of alpha emitters. New approaches in radiolabeling are necessary because chemical radiolabeling techniques are rendered sub-optimal due to the presence of recoil energy generated by alpha decay, which causes chemical bonds to break. This review attempts to cover, in a concise fashion, various aspects of physics, radiobiology, and production of alpha emitters, as well as highlight the main problems they present, with possible new approaches to mitigate those problems. Special emphasis is placed on the strategies proposed for managing recoil energy. We will also provide an account of the recent studies in vitro and in vivo preclinical investigations of α-particle therapy delivered by various nanosystems from different materials, including inorganic nanoparticles, liposomes, and polymersomes, and some carbon-based systems are also summarized.

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Section: Nanoradiopharmaceuticals Based On Alpha Emittersmentioning

confidence: 99%

Nanoradiopharmaceuticals Based on Alpha Emitters: Recent Developments for Medical Applications

et al. 2021

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“…The study [108] was devoted to the sorption / desorption of nuclear medical isotopes technetium, bismuth, yttrium, and radium on DND for potential use as carriers for their targeted delivery. For this purpose, the adsorption properties of Tc (VII, IV), Bi (III), Y (III), and Ra (II) were studied using industrial DND samples.…”

Section: Nanodiamonds In Biology and Medicinementioning

confidence: 99%

Detonation nanodiamonds: from synthesis theory to application practice

Dolmatov¹,

Shames

Ōsawa

et al. 2021

JAMT

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The review is devoted to the current state of research and advances in the production and study of the properties of detonation nanodiamonds (DND), their application in technology and medicine. New data on the theory and practice of DND synthesis for the last 1–5 years are considered and systematized. It is shown that the zone of chemical reactions (ZCR) during the blust of explosive materials (EM) is decisive for the fractal pre-diamond structure formation, the final region of the nanodiamonds (1/3–3/4 of the diameter of the explosive charge) formation is determined. The possibility of predicting the DND yield and the influence of parameters on the synthesis process of nanodiamonds from individual EMs of binary and ternary compositions is shown, their optimal formulations are determined. The optimal ZCR width and the existence time of chemical reactions have been identified. The dependence of the DND yield on the nitrogen content in the EM was shown. The most effective method of DND purification and the possibility of obtaining graphite-diamond compositions of a given formulation are presented. The most informative indicators of nanodiamonds characterization are given. The magnetic properties of nanodiamonds are considered and the identity of the properties of DNDs from different EMs is shown. The characteristics of new compositions based on DND are indicated: electrochemical coatings (gold and chromium-diamond), thermal pastes, diamond-containing polymer filaments for a 3D printer, fuel compositions, enterosorbents, compatible with biosystems of the nanodiamond-drug composition.

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“…Carbon nanostructures are also being studied as carriers of 223 Ra. In 2020, Kazakov et al [70] tested various materials as carriers for selected radionuclides, including 226 Ra radionuclide, as surrogate of 223 Ra. They reported that Ra 2+ sorption occurred only on reduced graphite oxide samples, and reaching 60% activity.…”

Section: Nanoconstructs Labelled With α-Emittersmentioning

confidence: 99%

Nanoparticles in Targeted Alpha Therapy

et al. 2020

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Recent advances in the field of nanotechnology application in nuclear medicine offer the promise of better therapeutic options. In recent years, increasing efforts have been made on developing nanoconstructs that can be used as carriers for immobilising alpha (α)-emitters in targeted drug delivery. In this publication, we provide a comprehensive overview of available information on functional nanomaterials for targeted alpha therapy. The first section describes why nanoconstructs are used for the synthesis of α-emitting radiopharmaceuticals. Next, we present the synthesis and summarise the recent studies demonstrating therapeutic applications of α-emitting labelled radiobioconjugates in targeted therapy. Finally, future prospects and the emerging possibility of therapeutic application of radiolabelled nanomaterials are discussed.

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An experimental study of sorption/desorption of selected radionuclides on carbon nanomaterials: a quest for possible applications in future nuclear medicine

Cited by 23 publications

References 54 publications

Nanoradiopharmaceuticals Based on Alpha Emitters: Recent Developments for Medical Applications

Nanoradiopharmaceuticals Based on Alpha Emitters: Recent Developments for Medical Applications

Detonation nanodiamonds: from synthesis theory to application practice

Nanoparticles in Targeted Alpha Therapy

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