An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery

Okabe, Katsuhiko; Ueki, Koichiro; Marukawa, Kohei; Mukozawa, Aya; Miyazaki, Mutsuko; Nakagawa, Kiyomasa

doi:10.1016/j.tripleo.2010.02.033

Cited by 12 publications

(4 citation statements)

References 49 publications

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“…Although titanium is an effective biomaterial, it does not exhibit suitable absorption and must be removed by surgery. However, uHA/PLLA has been developed as a potentially useful biological material showing good absorption and bone conductivity; therefore, this material may facilitate bone tissue repair . Moreover, studies have reported the complete process of bioresorption and bone replacement of rods made of forged composites of unsintered hydroxyapatite particles/poly‐ l ‐lactide (F‐u‐HA/PLLA) implanted in the femoral medullary cavities of rabbits.…”

Section: Discussionmentioning

confidence: 99%

“…However, uHA/PLLA has been developed as a potentially useful biological material showing good absorption and bone conductivity; therefore, this material may facilitate bone tissue repair. [26][27][28][29] Moreover, studies have reported the complete process of bioresorption and bone replacement of rods made of forged composites of unsintered hydroxyapatite particles/poly-L-lactide (F-u-HA/PLLA) implanted in the femoral medullary cavities of rabbits. These studies showed that morphological changes during biodegradation and bone replacement in the proximal medullary cavity lasted for up to 4.5 years and that the molecular weight and bending strength decreased to 50 kDa and 200 MPa after 6 months.…”

Section: Discussionmentioning

confidence: 99%

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Effect on surface character and mechanical property of unsintered hydroxyapatite/poly‐l‐lactic acid (uHA/PLLA) material by UV treatment

Moroi

Okuno²,

Kobayashi³

et al. 2016

J Biomed Mater Res

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Materials fabricated with unsintered hydroxyapatite/poly‐l‐lactic acid (uHA/PLLA) exhibit biological activity and biocompatibility, but are also hydrophobic. This hydrophobicity limits the ability of cells or tissues to adhere to the surface of the material and thereby prevents the materials from exhibiting effective biological activity. In this study, we examined the effects of ultraviolet (UV) treatment on the hydrophobicity of uHA/PLLA. We compared the contact angle, mechanical strength, cell attachment, and cell differentiation capacity between untreated uHA/PLLA and uHA/PLLA treated with UV light. The contact angle of UV‐treated uHA/PLLA was significantly reduced compared with that of untreated uHA/PLLA. However, there were no differences in mechanical strength between untreated uHA/PLLA and UV‐treated uHA/PLLA. Notably, the ability of cells to adhere to UV‐treated uHA/PLLA was significantly increased compared with that of untreated uHA/PLLA. Similarly, there were significant differences between UV‐treated uHA/PLLA and untreated uHA/PLLA in alkaline phosphatase assays. These findings demonstrated that UV irradiation of uHA/PLLA improved the surface hydrophilicity without changing the mechanical strength of the material; thus, UV treatment of uHA/PLLA may facilitate the use of this material in biomedical applications. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 191–200, 2018.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effect on surface character and mechanical property of unsintered hydroxyapatite/poly‐l‐lactic acid (uHA/PLLA) material by UV treatment

Moroi

Okuno²,

Kobayashi³

et al. 2016

J Biomed Mater Res

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“…Prior to this clinical study, a previous study using rabbit suggested that the use of an absorbable plate (Super FIXSORB®-MX) in combination with Biopex® was useful and both Super FIXSORB®-MX and Biopex® could provide adequate bone regeneration and maintain strength and stability in the surgical bone space (Okabe et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

Assessment of bone healing and hypoesthesia in the upper lip after Le Fort I osteotomy with self-setting α-tricalcium phosphate and absorbable plates

Ueki

Okabe

Marukawa

et al. 2013

Journal of Cranio-Maxillofacial Surgery

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“…Therefore, they used the self-setting α-tricalcium phosphate (α-TCP; Biopex ® ) to fill the bone defects postoperatively, thus improving bone regeneration and long-term stability. A rabbit model study confirmed that the use of u-HA/PLLA plates with this material was beneficial, i.e., it could provide sufficient bone regeneration while maintaining strength and fixation in the surgical bone defect [ 193 ]. A 2013 study evaluated the postoperative changes in maxillary stability after Le Fort I osteotomy using u-HA/PLLA devices with or without α-TCP [ 194 ].…”

Section: Clinical Applications Of U-ha/plla In Oral and Maxillofacial Surgerymentioning

confidence: 99%

A Narrative Review of u-HA/PLLA, a Bioactive Resorbable Reconstruction Material: Applications in Oral and Maxillofacial Surgery

et al. 2021

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The advent of bioresorbable materials to overcome limitations and replace traditional bone-reconstruction titanium-plate systems for bone fixation, thus achieving greater efficiency and safety in medical and dental applications, has ushered in a new era in biomaterial development. Because of its bioactive osteoconductive ability and biocompatibility, the forged composite of uncalcined/unsintered hydroxyapatite and poly L-lactic acid (u-HA/PLLA) has attracted considerable interest from researchers in bone tissue engineering, as well as from clinicians, particularly for applications in maxillofacial reconstructive surgery. Thus, various in vitro studies, in vivo studies, and clinical trials have been conducted to investigate the feasibility and weaknesses of this biomaterial in oral and maxillofacial surgery. Various technical improvements have been proposed to optimize its advantages and limit its disadvantages. This narrative review presents an up-to-date, comprehensive review of u-HA/PLLA, a bioactive osteoconductive and bioresorbable bone-reconstruction and -fixation material, in the context of oral and maxillofacial surgery, notably maxillofacial trauma, orthognathic surgery, and maxillofacial reconstruction. It simultaneously introduces new trends in the development of bioresorbable materials that could used in this field. Various studies have shown the superiority of u-HA/PLLA, a third-generation bioresorbable biomaterial with high mechanical strength, biocompatibility, and bioactive osteoconductivity, compared to other bioresorbable materials. Future developments may focus on controlling its bioactivity and biodegradation rate and enhancing its mechanical strength.

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An experimental study of use of absorbable plate in combination with self-setting α-tricalcium phosphate for orthognathic surgery

Cited by 12 publications

References 49 publications

Effect on surface character and mechanical property of unsintered hydroxyapatite/poly‐l‐lactic acid (uHA/PLLA) material by UV treatment

Effect on surface character and mechanical property of unsintered hydroxyapatite/poly‐l‐lactic acid (uHA/PLLA) material by UV treatment

Assessment of bone healing and hypoesthesia in the upper lip after Le Fort I osteotomy with self-setting α-tricalcium phosphate and absorbable plates

A Narrative Review of u-HA/PLLA, a Bioactive Resorbable Reconstruction Material: Applications in Oral and Maxillofacial Surgery

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