An experimental study on the biocompatibility of lining cements based on glass ionomer as compared with calcium hydroxide

Müller, Jan-Dirk; Hörz, Wolfram; Brückner, Gert; Kraft, Erik

doi:10.1016/0109-5641(90)90042-d

Cited by 17 publications

(5 citation statements)

References 20 publications

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“…A previous study reported that PDL fibroblast cells exposed to undiluted elutes of Ketac Molar for 3 days had a 50% decrease in cell viability as compared with MTA (28). Furthermore, the cytotoxic effect of GIC on pulp cells was stronger than that of calcium hydroxide, even after a 2-day hardening period (29). The cytotoxicity of GIC is generally attributed to their acidity and release of fluoride (30) and aluminum (31), but toxicity varies by product (32).…”

Section: Discussionmentioning

confidence: 99%

<i>In vitro</i> cytotoxic evaluation of novel fast-setting calcium silicate cement compositions and dental materials using colorimetric methyl-thiazolyl-tetrazolium assay

et al. 2018

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A novel fast-setting calcium silicate cement with fluoride (CSC) has been developed for potential application in tooth crowns. This study compared the cytotoxicity of CSC compositions and a variety of dental materials. We tested CSC compositions (Protooth), MTA, Biodentine, Ketac Molar, Fuji II LC, Vitrebond, DeTrey Zinc, Dycal, and IRM, DMEM (negative control) and 1% NaOCl (positive control). After setting of cements for 24 h, specimens were immersed in DMEM for 24 h to obtain material elutes. The elutes were serially diluted in serum-free DMEM to obtain three dilutions. L929 mouse fibroblast cells (1 × 10 cells per well) were treated for 24 h with elute dilutions (n = 3). Cytotoxicity was determined using methyl-thiazolyl-tetrazolium assay in triplicate. CSC compositions, MTA, and Biodentine showed no significant reduction in cell viability compared to DMEM. There was no significant difference in cell viability, at any of three dilutions, between CSC compositions and either MTA or Biodentine. Cytotoxicity was significantly lower for CSC compositions than for Vitrebond, DeTrey Zinc, Dycal, IRM, and 1% NaOCl, at all three dilutions, and undiluted Fuji II LC elute. In contrast to resin-modified glass ionomers, zinc phosphate cements, Dycal, and IRM, the CSC compositions showed no cytotoxic potential.

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Section: Discussionmentioning

confidence: 99%

<i>In vitro</i> cytotoxic evaluation of novel fast-setting calcium silicate cement compositions and dental materials using colorimetric methyl-thiazolyl-tetrazolium assay

et al. 2018

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“…The conventional formulations tend to be less toxic than the resin-modified formulations 57,59,63–64. This should not be construed as an indictment against the use of GI/RMGI in deep cavities.…”

Section: Direct Pulp Capping Materialsmentioning

confidence: 99%

Keys to Clinical Success with Pulp Capping: A Review of the Literature

Hilton¹

2009

Operative Dentistry

314

283

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“…Studies by Muller on the cytotoxicity of calcium-hydroxide cement found different degrees of relative tissue culture growth in Dyract and KERR (6). By the third day of the experiment, it was between 75%-99% (grade 4 according to the index of Nacamura, 1983).…”

Section: Discussionmentioning

confidence: 95%

A study of the cytotoxicity of resin-modified glass-ionomer cement

Kirilova

2024

MedInform

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Background. It is crucial to maintain the vitality of the dental pulp by using biologically tolerable materials when placed on dentin near the dental pulp. Calcium-hydroxide cement has been established as such a material.Resin-modified Glass-ionomer cement (RMGIC) is another group of materials. The results on the biological tolerance of different types are contradictory.Aim. Therefore, we conducted a study to compare the cytotoxicity of glass-ionomer cement available in powder and liquid packages with individual capsule doses on cell cultures. Material and methods.The materials used in this study are zink phosphate cement AdhesorTM Fine (GR.1), resinmodified glass-ionomer cement Fiji LC II (Gr.2) powder-liquid package; Fiji LC II (Gr3) individual capsules package, calcium-hydroxide cement Basic L (Gr.4). The study was conducted on human skin-muscle embryonic fibroblasts (diploid cells) cell cultures.Results. The study's results indicate that RMGIC Fuji LC II and calcium-hydroxide cement studies have approximately the same degree of relative growth on cell cultures. However, in powder-liquid packaging, the results deteriorate over time, while individual ones retain their qualities.Conclusions. The present study's limitation is that RMGIC packages influenced the materials' cytotoxicity degree.Individual capsules of RMGIC had a better degree of cytotoxicity close to the calcium-hydroxide cement. Further research is needed along these lines.

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An experimental study on the biocompatibility of lining cements based on glass ionomer as compared with calcium hydroxide

Cited by 17 publications

References 20 publications

<i>In vitro</i> cytotoxic evaluation of novel fast-setting calcium silicate cement compositions and dental materials using colorimetric methyl-thiazolyl-tetrazolium assay

<i>In vitro</i> cytotoxic evaluation of novel fast-setting calcium silicate cement compositions and dental materials using colorimetric methyl-thiazolyl-tetrazolium assay

Keys to Clinical Success with Pulp Capping: A Review of the Literature

A study of the cytotoxicity of resin-modified glass-ionomer cement

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