A fire can pose a significant threat to a building’s occupants and leads to property damage. The burning characteristics usually determine the severity of the accident. Environments in high-altitude areas feature low oxygen content and ambient pressure, which can influence the burning characteristics of combustibles. In this paper, a series of field experiments were conducted to investigate the burning characteristics of gasoline at different altitudes considering heat release rate (HRR), flame height, and smoke release rate. Results show that the combustion process can be divided into three stages: initial stage, stable stage, and attenuation stage. Lower oxygen content and ambient pressure reduce the HRR; for example, the HRR at an altitude of 4150 m is nearly half at an altitude of 500 m, contributing to a lower smoke release rate. The HRR is proportional to 1.3 power of atmospheric pressure, and a fitting equation was brought out in this paper. Flame height increases with the increase in altitude due to the demand for more oxygen during the combustion process since the oxygen content is low in high-altitude areas.