An exploration of alternative therapeutic targets for aortic disease in Marfan syndrome

Van Den Heuvel, Lotte J.F.; Peeters, Silke; Meester, Josephina A.N.; Coucke, Paul J.; Loeys, Bart L.

doi:10.1016/j.drudis.2024.104023

Drug Discovery Today

2024

DOI: 10.1016/j.drudis.2024.104023

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An exploration of alternative therapeutic targets for aortic disease in Marfan syndrome

Lotte J.F. Van Den Heuvel,

Silke Peeters,

Josephina A.N. Meester

et al.

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2024

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Cited by 1 publication

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Copper ions: The invisible killer of cardiovascular disease (Review)

Wang,

Feng,

et al. 2024

Mol Med Rep

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Copper, a vital trace element, is indispensable for the maintenance of physiological functioning, particularly in the cardiac system. Unlike other forms of cell death such as iron death and apoptosis, copper-induced cell death has gained increasing recognition as a significant process influencing the development of cardiovascular diseases. The present review highlights the significance of maintaining copper homeostasis in addressing cardiovascular diseases. This review delves into the crucial roles of copper in physiology, including the metabolic pathways and its absorption, transport and excretion. It provides detailed insights into the mechanisms underlying cardiovascular diseases resulting from both excess and deficient copper levels. Additionally, it summarizes strategies for treating copper imbalances through approaches such as copper chelators and ion carriers while discussing their limitations and future prospects.

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Copper ions: The invisible killer of cardiovascular disease (Review)

Wang,

Feng,

et al. 2024

Mol Med Rep

View full text Add to dashboard Cite

show abstract

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An exploration of alternative therapeutic targets for aortic disease in Marfan syndrome

Cited by 1 publication

References 75 publications

Copper ions: The invisible killer of cardiovascular disease (Review)

Copper ions: The invisible killer of cardiovascular disease (Review)

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