Although it is evident that working with cancer patients can be stressful, explanations have differed as to why this is so and little attention has been paid to the rewards of this work. One hundred ninety clinical staff members at a comprehensive cancer center representing 91% of eight disciplines studied were interviewed using a semistructured format about the factors influencing their job satisfaction. The fact that the staff members almost uniformly rated their satisfaction as high (8.2 on a scale of 1 to 10) precluded the detection of discriminating variables. Satisfaction with the way they met their goals also was'high; most identified potentially achievable goals, relied heavily on the interdisciplinary team, and experienced changes in their attitudes and approach during their first 2 years in the field, primarily increased realism. A major discomfort for physicians was the inability to provide optimal care. Ethical issues were a major discomfort for nurses. Death itself and staff conflict were less important sources of discomfort than in previous reports.Cancer 64:975-982, 1989.HE DIFFICULTY that many oncology units encounter T in maintaining adequate numbers of qualified staff members has generated considerable interest in the factors influencing job satisfaction and staff turnover. With a few notable exceptions, the literature has focused on single explanations of stress. Some authors have emphasized the discomfort associated with proximity to death, noting a tendency of certain staff members to withdraw emotionally from dying patients.',' Others have described "burn out" from overinvolvement with the patient's and identify the major difficulty for staff members as maintaining appropriate expectations of themselve~.~.~ Still others have located the real problem in the work envir~nment,'.~ emphasizing the importance of the relationships among members of the treatment team. The most comprehensive model of occupational stress is that proposed by Vachon: who describes an interaction among several variables including the particular challenges of the work, the attributes that individuals bring to it, the characteristics of the work setting, and the coping mechanisms that staff members develop. Her observations, based on informal interviews with many caregivers in a variety of clinical settings, are the most extensive currently.