This study provides answers to questions about the mechanisms of innovative stress as a reaction of the human brain to colossal nervous overloads, factors of information stress, and the modern vision of the theory of psychological stress caused by an abundance of information. A significant part of the study is devoted to the problems caused by the stress of the need to adopt innovations in countries with a low level of computer literacy, as exemplified by Azerbaijan. Azerbaijan is being assessed as a country with an economy in transition. The workforce of the organizations is estimated as a key resource for the implementation of innovations and ensuring their viability. Significant difficulties in adapting specialists to the changing content of activities and new working conditions are considered the main reasons for the development and exacerbation of the professional stress of employees in a situation of organizational transformation.